ReviewJournal of clinical medicine2022
Prevalence of Ocular Anomalies in Craniosynostosis: A Systematic Review and Meta-Analysis.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Distraction in anterior plagiocephaly: technique, risks, and long-term results.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Two-Year Progressive Cranial Changes Following the Melbourne Technique for Sagittal Craniosynostosis.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Strabismus in Genetic Syndromes: A Review.Clinical & experimental ophthalmology · 2025Review
- Article
- Ocular manifestations and treatment progress of Crouzon syndrome.International ophthalmology · 2024Review
- The Outcome of Inferior Oblique Myectomy for Apparent Inferior Oblique Overaction Associated with Craniosynostosis.Korean journal of ophthalmology : KJO · 2024Article
- Craniosynostosis incidence with abnormalities of orbital axis on patients under 8 years old.Surgical neurology international · 2024Article
- Syndromic Craniosynostosis: A Comprehensive Review.Cureus · 2023Review
- Pre-Operative Ocular Findings and Long-Term Follow-Up in a Large Cohort of Non-Syndromic Unicoronal Craniosynostosis.Journal of clinical medicine · 2023Article
- Torticollis in Non-Syndromic Unicoronal Craniosynostosis Is Predominantly Ocular Related.Journal of clinical medicine · 2023Article
- Effect of Midface Surgery on Ocular Outcomes in Patients with Orbital and Midface Malformations.Journal of clinical medicine · 2023Article
- Orbital Foraminal Morphometrics in Nonsyndromic Unilateral Coronal Craniosynostosis.Annals of plastic surgery · 2023Article
- A unique presentation of Crouzon-like syndrome: Complex craniosynostosis in the absence of genetic mutations or familial predisposition - A case report.Surgical neurology international · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe aim of this study was to describe the ophthalmic abnormalities and their prevalence in craniosynostosis prior to craniofacial surgery.
methodsA systematic search was conducted on Medline OVID, Embase, Cochrane, Google Scholar, Web of Science Core Collection. Inclusion criteria were English papers, children aged <18 years with non-syndromic and syndromic craniosynostosis, case reports, case series, and case-control studies. A system of domains was established consisting of an anatomic and functional ophthalmic domain. A meta-analysis of single proportions was carried out using random effects model and pooled mean proportions with 95% confidence intervals (CI) were calculated.
resultsThirty-two papers analyzing 2027 patients were included. Strabismus was the most common anomaly in non-syndromic craniosynostosis: Horizontal strabismus was highest prevalent in unicoronal craniosynostosis (UCS) 19% (95% CI 9-32), followed by vertical strabismus 17% (95% CI 5-33). In syndromic craniosynostosis, horizontal strabismus was most prevalent in Crouzon syndrome 52% (95 CI 26-76), followed by Apert syndrome 50% (95% CI 42-58). Vertical strabismus was most prevalent in Saethre-Chotzen 60% followed by Muenke's syndrome 36%. Furthermore, astigmatism was the second most reported outcome in non-syndromic craniosynostosis and highest prevalent in UCS 35% (95% CI 21-51). In syndromic craniosynostosis, astigmatism was most frequently seen in Crouzon syndrome 43% (95% CI 22-65), followed by Apert syndrome 34% (95% CI 14-58). Moreover, in syndromic craniosynostosis, 5-40% had a decrease in visual acuity (VA) ≤ 0.3 LogMAR in the better eye and 11-65% had a VA ≤ 0.3 LogMAR in at least one eye. DISCUSSION: This review demonstrates the high prevalence of ocular anomalies in non-syndromic and syndromic craniosynostosis. A multidisciplinary and systematic approach is needed for the screening and optimal treatment of these conditions in a timely manner.
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