Evidence map›Paper›PMID 35207297›Full record

ArticleJournal of clinical medicine2022

Prediction of Acute Kidney Injury by Cystatin C and [TIMP-2]*[IGFBP7] after Thoracic Aortic Surgery with Moderate Hypothermic Circulatory Arrest.

Kevin Pilarczyk, Bernd Panholzer, Katharina Huenges, Mohamed Salem, Toni Jacob, Jochen Cremer, Assad Haneya

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kevin PilarczykDepartment of Intensive Care Medicine, Imland Klinik Rendsburg, 24768 Rendsburg, Germany.ORCID 0000-0001-7788-1174
Bernd PanholzerDepartment of Cardiovascular Surgery, University of Schleswig-Holstein, 24105 Kiel, Germany.ORCID 0000-0002-4992-818X
Katharina HuengesDepartment of Cardiovascular Surgery, University of Schleswig-Holstein, 24105 Kiel, Germany.ORCID 0000-0002-4329-9087
Mohamed SalemDepartment of Cardiovascular Surgery, University of Schleswig-Holstein, 24105 Kiel, Germany.ORCID 0000-0002-0106-8205
Toni JacobDepartment of Cardiovascular Surgery, University of Schleswig-Holstein, 24105 Kiel, Germany.ORCID 0000-0002-5610-6088
Jochen CremerDepartment of Cardiovascular Surgery, University of Schleswig-Holstein, 24105 Kiel, Germany.
Assad HaneyaDepartment of Cardiovascular Surgery, University of Schleswig-Holstein, 24105 Kiel, Germany.
Christian-Albrechts-Universität zu Kiel · DEInstitut für Berufliche Aus- und Fortbildung · DE

Funding

Astute Medical This study was supported by Astute Medical that provided the ASTUTE Meter 140 and the test kits. Apart from that, the study was fully financed with departmental funds. The company had no influence on the design, conduct or data analysis of the study or on
6 · The paper itself

Abstract

(1) Background: Acute kidney injury (AKI) is a common complication following thoracic aortic surgery (TAS), with moderate hypothermic circulatory arrest (MHCA). However, prediction of AKI with classical tools remains uncertain. Therefore, it was the aim of the present study to evaluate the role of new biomarkers in patients after MHCA. (2) Methods: 101 consecutive patients were prospectively enrolled. Measurements of urinary [TIMP-2]*[IGFBP7] and Cystatin C in the blood were performed perioperatively. Primary endpoint was the occurrence of AKI stage 2 or 3 (KDIGO-classification) within 48 h after surgery (AKI group). (3) Results: Mean age of patients was 69.1 ± 10.9 years, 35 patients were female (34%), and 13 patients (13%) met the primary endpoint. Patients in the AKI group had a prolonged ICU-stay (6.9 ± 7.4 days vs. 2.5 ± 3.1 days,

Indexed as

acute kidney injurybiomarkerscell cycle arrest markersCystatinhypothermic circulatory arrestthoracic aortic surgery

Identifiers

PMID35207297
PMCPMC8877349
OpenAlexW4213057784

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.