Evidence map›Paper›PMID 35207269›Full record

ArticleJournal of clinical medicine2022

Biliary Atresia in 2021: Epidemiology, Screening and Public Policy.

Richard A Schreiber, Sanjiv Harpavat, Jan B F Hulscher, Barbara E Wildhaber

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07139717 (Evaluation of the Effectiveness of Stool Color Card in the Early Detection of Biliary Atresia), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07139717 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Effectiveness of Stool Color Card in the Early Detection of Biliary Atresia: A Prospective Study.

TypeobservationalSponsorAssiut UniversityRan2025 to 2026Enrolled100ConditionsStool Color Card, Biliary Atresia
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Towards a reference cell atlas of liver diversity over the human lifespan.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Late Referral of Biliary Atresia and Poor Clinical Outcomes.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
    Observational
  8. Incidence and outcome of biliary atresia in the United Arab Emirates: A multicenter national study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025
    Article
  9. Review
  10. Dramatic Extrahepatic Cholestasis Improvement after Steroid Therapy.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Expansion of CD103Frontiers in immunology · 2025
    Article
  15. Review
  16. The Assessment and Management of Biliary Atresia in Hawai'i, 2009-2023.Hawai'i journal of health & social welfare · 2024
    Article
  17. Article
  18. Article
  19. Primary liver transplantationWorld journal of transplantation · 2024
    Article
  20. Diseases of bile duct in children.World journal of gastroenterology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Richard A SchreiberDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.ORCID 0000-0002-0330-3811
Sanjiv HarpavatDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA.
Jan B F HulscherDepartment of Surgery, Division of Pediatric Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Barbara E WildhaberSwiss Pediatric Liver Center, Division of Pediatric Surgery, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, 1205 Geneva, Switzerland.ORCID 0000-0003-4548-382X
Baylor College of Medicine · USUniversity Medical Center Groningen · NLUniversity of British Columbia · CAUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biliary atresia (BA) is a rare newborn liver disease with significant morbidity and mortality, especially if not recognized and treated early in life. It is the most common cause of liver-related death in children and the leading indication for liver transplantation in the pediatric population. Timely intervention with a Kasai portoenterostomy (KPE) can significantly improve prognosis. Delayed disease recognition, late patient referral, and untimely surgery remains a worldwide problem. This article will focus on biliary atresia from a global public health perspective, including disease epidemiology, current national screening programs, and their impact on outcome, as well as new and novel BA screening initiatives. Policy challenges for the implementation of BA screening programs will also be discussed, highlighting examples from the North American, European, and Asian experience.

Indexed as

biliary atresiaepidemiologynewborn screeningpediatric liver diseasepublic health

Identifiers

PMID35207269
PMCPMC8876662
OpenAlexW4213029344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.