Evidence map›Paper›PMID 35207258›Full record

ArticleJournal of clinical medicine2022

Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019.

Hideo Wada, Yuhuko Ichikawa, Minoru Ezaki, Akitaka Yamamoto, Masaki Tomida, Masamichi Yoshida, Shunsuke Fukui, Isao Moritani, Katsuya Shiraki, Motomu Shimaoka and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. The Effect of Antiplatelet Therapy on COVID-19.Juntendo Iji zasshi = Juntendo medical journal · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Biomarkers of Hypercoagulability in COVID-19.Journal of clinical medicine · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Super Formula for Soluble C-Type Lectin-Like Receptor 2 × D-Dimer in Patients With Acute Cerebral Infarction.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
  15. The Impact of Prior Antithrombotic use on Thromboembolic Events in Patients with Cardiovascular Disease and Severe COVID-19 Infection.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Hideo WadaDepartment of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.ORCID 0000-0001-9021-8633
Yuhuko IchikawaDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.
Minoru EzakiDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.
Akitaka YamamotoDepartment of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.
Masaki TomidaDepartment of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.
Masamichi YoshidaDepartment of Respiratory Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.
Shunsuke FukuiDepartment of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.
Isao MoritaniDepartment of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.
Katsuya ShirakiDepartment of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.
Motomu ShimaokaDepartment of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
Toshiaki IbaDepartment of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0002-0255-4088
Katsue Suzuki-InoueDepartment of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Hideto ShimpoMie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.
Mie Chuo Medical Center · JPJuntendo University · JPMie University · JPUniversity of Yamanashi · JP

Funding

the Ministry of Health, Labour and Welfare of Japan, LSI Medience H30-025
6 · The paper itself

Abstract

Although thrombosis in coronavirus disease 2019 (COVID-19) infection has attracted attention, the mechanism underlying its development remains unclear. The relationship between platelet activation and the severity of COVID-19 infection was compared with that involving other infections. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2) levels were measured in 46 patients with COVID-19 infection and in 127 patients with other infections. The plasma sCLEC-2 levels in patients with COVID-19 infection {median (25th, 75th percentile), 489 (355, 668) ng/L} were significantly higher (

Indexed as

coagulopathyCOVID-19platelet activationsCLEC-2

Identifiers

PMID35207258
PMCPMC8877880
OpenAlexW4212846097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.