Evidence map›Paper›PMID 35207218›Full record

ArticleJournal of clinical medicine2022

Mid-Term Impact of Anti-Vascular Endothelial Growth Factor Agents on Intraocular Pressure.

Marc-Antoine Hannappe, Florian Baudin, Anne-Sophie Mariet, Pierre-Henri Gabrielle, Louis Arnould, Alain M Bron, Catherine Creuzot-Garcher

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. It Is All about Pressure.Journal of clinical medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Marc-Antoine HannappeOphthalmology Department, University Hospital of Dijon, 21000 Dijon, France.
Florian BaudinOphthalmology Department, University Hospital of Dijon, 21000 Dijon, France.ORCID 0000-0003-4976-9876
Anne-Sophie MarietINSERM, CIC 1432, Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Burgundy University, 21000 Dijon, France.ORCID 0000-0003-0134-1248
Pierre-Henri GabrielleOphthalmology Department, University Hospital of Dijon, 21000 Dijon, France.
Louis ArnouldOphthalmology Department, University Hospital of Dijon, 21000 Dijon, France.ORCID 0000-0001-7831-8818
Alain M BronOphthalmology Department, University Hospital of Dijon, 21000 Dijon, France.ORCID 0000-0002-7265-931X
Catherine Creuzot-GarcherOphthalmology Department, University Hospital of Dijon, 21000 Dijon, France.
Centre National de la Recherche Scientifique · FRInserm · FRMaison des Sciences sociales et des Humanités de Dijon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of intraocular injections of anti-vascular endothelial growth factor (VEGF) on intraocular pressure (IOP) has not been clearly stated. We extracted data from the electronic health records at Dijon University Hospital of 750 patients who were unilaterally injected with anti-VEGF agents between March 2012 and March 2020. These were treatment-naïve patients who had received at least three injections of the same treatment (aflibercept, bevacizumab, or ranibizumab) in one eye only, and had IOP measurements before and after the injections. Fellow untreated eyes were used as comparators. A clinically significant IOP rise was determined as an IOP above 21 mmHg and an increase of at least 6 mmHg compared to baseline, or the need for IOP-lowering agents. We found an overall slight increase in IOP between treated and untreated eyes at 6 months (+0.67 ± 3.33 mmHg, 95% confidence interval 0.33-1.02,

Indexed as

anti-VEGF agentsintraocular pressureintravitreal injection

Identifiers

PMID35207218
PMCPMC8879175
OpenAlexW4212984245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.