ArticleInternational journal of environmental research and public health2022
Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Disconnection from social others: a RULS Loneliness Short Scale.Current issues in personality psychology · 2026Article
- The Moderating Effects of Moral Injury and Discrimination Trauma on Women Physician Trainees' Well-Being.Journal of general internal medicine · 2025Article
- Stress-related gene regulation: Do isolated and connected individuals differ?Brain, behavior, and immunity · 2024Article
- Occupational burnout, flourishing and job satisfaction among HIV/AIDS healthcare workers in Western China: a network analysis.BMC psychiatry · 2023Article
- Higher exposure to childhood adversity associates with lower adult flourishing.BMC public health · 2022Article
- Potential effects of shift work on skin autoimmune diseases.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While much attention has been paid to healthcare provider and trainee burnout, less is known about provider well-being (i.e., flourishing) or about the effects of well-being on immune function. This study examined the demographic and psycho-social correlates of well-being among healthcare trainees (resident physicians and physician assistant (PA) trainees) and evaluated the association of well-being with the "conserved transcriptional response to adversity" (CTRA) characterized by up-regulated expression of pro-inflammatory genes and down-regulated expression of innate antiviral genes. Participants (n = 58) completed self-reported assessments of sleep disturbance, loneliness, depressive symptoms, anxiety, stress, and well-being (flourishing). Blood sample RNA profiles were analyzed by RNA sequencing to assess the CTRA. Slightly over half (n = 32; 55.2%) of healthcare trainees were categorized as flourishing. Flourishing was less prevalent among primary caregivers, and more prevalent among trainees who exercised more frequently and those with fewest days sick. Loneliness (AOR = 0.75; 95% CI = 0.61, 0.91;
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Registered trials
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