ArticleInternational journal of environmental research and public health2022
Association between Bone Lead Concentration and Aggression in Youth from a Sub-Cohort of the Birth to Twenty Cohort.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Lead exposure and antisocial behavior: A systematic review of human and animal evidence.Environment international · 2025Pooled it
- Lead exposure, glucocorticoids, and physiological stress across the life course: A systematic review.Environmental pollution (Barking, Essex : 1987) · 2024Pooled it
- Developmental lead exposure and aggression in male rats: Influences of maternal care and environmental enrichment.Toxicology reports · 2025Article
- The influence of contemporary and emerging factors on blood lead concentrations among young males in conflict with the law: a case study from a middle-income country.Frontiers in epidemiology · 2024Article
- The association between lead exposure and crime: A systematic review.PLOS global public health · 2023Article
- Differences in Driving Anger among Professional Drivers: A Cross-Cultural Study.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAn association between blood-lead levels and aggression has been demonstrated in children and adolescent youth in South Africa. However, there are limited studies that have assessed aggression as an outcome for cumulative lead exposure using bone lead concentration. This study aims to assess the association between bone lead concentration and aggressive behaviour among a sample of youth in South Africa.
methodsBone lead in 100 participants (53 males and 47 females) recruited and followed in the Birth to Twenty (BT20) Cohort were measured using 109 Cd-based, K-shell X-ray fluorescence (KXRF). The Buss-Perry Aggression questionnaire was used to measure aggressive behaviour. Linear regression models were fitted to determine the association between aggression score for physical, verbal, anger and hostility and bone lead, adjusting for known confounders.
resultsA one-microgram-per-gram increase in bone lead was found to increase the score for all four scales of aggression, but significantly only for anger (β = 0.2 [95% CI 0.04-0.370]). Psychosocial factors such as a history of family violence and exposure to neighbourhood crime were significant predictors for aggression.
conclusionsThe study provides a preliminary overview of the relationship between cumulative lead exposure and behavioural problems such as aggression. A larger sample, across exposed communities, may prove more definitive in further investigating the association between these two important public health factors and to maximize generalizability.
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