Observational studyInternational journal of environmental research and public health2022
Dental Consequences of Vitamin D Deficiency during Pregnancy and Early Infancy-An Observational Study.
Observational study in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 7 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Influence of Vitamin D on Developmental Defects of Enamel (DDE) in Children and Adolescents: A Systematic Review.Nutrients · 2025Pooled it
- Vitamin D deficiency and oral health: a systematic review of literature.BMC oral health · 2025Pooled it
- Are low serum levels of Vitamin D associated with dental developmental defects in primary teeth? A systematic review.Evidence-based dentistry · 2024Pooled it
- Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Examining the Role of Vitamin D in Caries Susceptibility in Children's Deciduous Teeth: A Systematic Review.Nutrients · 2023Pooled it
- The Impact of Prenatal Vitamin D on Enamel Defects and Tooth Erosion: A Systematic Review.Nutrients · 2023Pooled it
- Associations of Prenatal Vitamin D status with Oral Health in Offspring: A Systematic Review.Oral health & preventive dentistry · 2022Pooled it
- Generalized Developmental Enamel Hypoplasia of the Permanent Dentition Associated with Early Childhood Vitamin D Deficiency Rickets: A Case Report.Dentistry journal · 2026Article
- Vitamin D Levels During Pregnancy and Dental Caries in Offspring.JAMA network open · 2025Article
- The effect of folic acid or multivitamin containing folic acid supplementation during pregnancy on enamel structure of deciduous teeth: an ultrastructural and microanalytical study.Head & face medicine · 2025Article
- Association of prenatal vitamin D concentration with the eruption time of the first primary tooth: A prospective cohort study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Roles of calcium in ameloblasts during tooth development: A scoping review.Journal of Taibah University Medical Sciences · 2025Review
- Influences of Maternal Nutrition and Lifestyle Factors on Early Childhood Oral Health: A Systematic Review of Mechanisms and Intervention Strategies.Children (Basel, Switzerland) · 2024Review
- Relationship between Maternal Prenatal Vitamin D Status and Early Childhood Caries in Their Children: A Cross-sectional Survey.International journal of clinical pediatric dentistry · 2024Article
- The association between serum vitamin D status and dental caries or molar incisor hypomineralisation in 7-9-year-old Norwegian children: a cross-sectional study.BMC public health · 2024Article
- Association between Malnutrition and Dental Caries in Iraqi Kurdish Children.Dentistry journal · 2023Article
- New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden.Diagnostics (Basel, Switzerland) · 2022Review
- Vitamin D, oral health, and disease characteristics in juvenile idiopathic arthritis: a multicenter cross-sectional study.BMC oral health · 2022Article
- Healthy Food, Healthy Teeth: A Formative Study to Assess Knowledge of Foods for Oral Health in Children and Adults.Nutrients · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D (25OHD) status during pregnancy is closely correlated with foetal and new-born 25OHD. Calcification for primary teeth begins from the fourth month of intrauterine life and from birth for permanent teeth. Dental consequences of severe 25OHD deficiency are well documented; however, consequences are less documented for milder degrees of 25OHD deficiency. This study examined the dental consequences of vitamin D deficiency/insufficiency during gestation and infancy in a cohort of 81 New Zealand children. Pregnancy and birth data for the children and their mothers and 25OHD status during gestation, birth and at five months were obtained, and dental examinations were conducted. Associations between 25OHD and enamel defects or caries experience were investigated. Of the 81 children, 55% had experienced dental caries and 64% had at least one enamel defect present. Vitamin D insufficiency (25OHD < 50 nmol/L) at all timepoints was not associated with enamel defect prevalence, but during third trimester pregnancy it was associated with an increased caries risk IRR of 3.55 (CI 1.15-10.92) by age 6. In conclusion, maternal 25OHD insufficiency during the third trimester of pregnancy was associated with greater caries experience in primary dentition. No association was found between early life 25OHD and enamel defect prevalence or severity.
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