Evidence map›Paper›PMID 35205926›Full record

ArticleJournal of fungi (Basel, Switzerland)2022

Molecular Profiling Reveals Characteristic and Decisive Signatures in Patients after Allogeneic Stem Cell Transplantation Suffering from Invasive Pulmonary Aspergillosis.

Tamara Zoran, Bastian Seelbinder, Philip Lewis White, Jessica Sarah Price, Sabrina Kraus, Oliver Kurzai, Joerg Linde, Antje Häder, Claudia Loeffler, Goetz Ulrich Grigoleit and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Tamara ZoranDepartment of Internal Medicine II, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
Bastian SeelbinderSystems Biology and Bioinformatics Unit, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, 07745 Jena, Germany.ORCID 0000-0002-7458-5289
Philip Lewis WhitePublic Health Wales, Microbiology Cardiff, UHW, Cardiff CF14 4XW, UK.
Jessica Sarah PricePublic Health Wales, Microbiology Cardiff, UHW, Cardiff CF14 4XW, UK.
Sabrina KrausDepartment of Internal Medicine II, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
Oliver KurzaiResearch Group Fungal Septomics, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, 07745 Jena, Germany.ORCID 0000-0002-7277-2646
Joerg LindeFriedrich-Loeffler Institute, Institute of Bacterial Infections and Zoonoses, 07743 Jena, Germany.
Antje HäderResearch Group Fungal Septomics, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, 07745 Jena, Germany.
Claudia LoefflerDepartment of Internal Medicine II, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
Goetz Ulrich GrigoleitDepartment of Internal Medicine II, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
Hermann EinseleDepartment of Internal Medicine II, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0002-7680-0819
Gianni PanagiotouSystems Biology and Bioinformatics Unit, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, 07745 Jena, Germany.
Juergen LoefflerDepartment of Internal Medicine II, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
Sascha SchäubleSystems Biology and Bioinformatics Unit, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, 07745 Jena, Germany.ORCID 0000-0003-3862-6546
Universitätsklinikum Würzburg · DELeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEPublic Health Wales · GBFriedrich-Loeffler-Institut · DE

Funding

Deutsche Forschungsgemeinschaft 210879364Free State of Thuringia and the European Social Fund 2016 FGR 0053
6 · The paper itself

Abstract

Despite available diagnostic tests and recent advances, diagnosis of pulmonary invasive aspergillosis (IPA) remains challenging. We performed a longitudinal case-control pilot study to identify host-specific, novel, and immune-relevant molecular candidates indicating IPA in patients post allogeneic stem cell transplantation (alloSCT). Supported by differential gene expression analysis of six relevant in vitro studies, we conducted RNA sequencing of three alloSCT patients categorized as probable IPA cases and their matched controls without

Indexed as

alloSCT patientscaspase-3galectin-2host responseinvasive pulmonary aspergillosismatrix metallopeptidase-1

Identifiers

PMID35205926
PMCPMC8880021
OpenAlexW4210979106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.