Evidence map›Paper›PMID 35205918›Full record

ReviewJournal of fungi (Basel, Switzerland)2022

Fungal Endophytes: A Potential Source of Antibacterial Compounds.

Sunil K Deshmukh, Laurent Dufossé, Hemraj Chhipa, Sanjai Saxena, Girish B Mahajan, Manish Kumar Gupta

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 93 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Enzymatic Glycosylation ofBiomolecules · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. NewStudies in mycology · 2024
    Article
  10. Article
  11. In Vitro Pharmacological Activity ofArchives of Razi Institute · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Two New Compounds from the Endophytic Fungi ofMolecules (Basel, Switzerland) · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Sunil K DeshmukhTERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute, Darbari Seth Block, IHC Complex, Lodhi Road, New Delhi 110003, Delhi, India.ORCID 0000-0001-5395-9512
Laurent DufosséChimie et Biotechnologie des Produits Naturels (CHEMBIOPRO Lab) & ESIROI Agroalimentaire, Université de la Réunion, 15 Avenue René Cassin, 97744 Saint-Denis, France.ORCID 0000-0001-7392-355X
Hemraj ChhipaCollege of Horticulture and Forestry, Agriculture University Kota, Jhalawar 322360, Rajasthan, India.ORCID 0000-0001-7591-848X
Sanjai SaxenaAgpharm Bioinnovations LLP, Incubatee: Science and Technology Entrepreneurs Park (STEP), Thapar Institute of Engineering and Technology, Patiala 147004, Punjab, India.ORCID 0000-0003-0025-8362
Girish B MahajanHiMedia Laboratories Pvt. Ltd., Mumbai 400086, Maharashtra, India.ORCID 0000-0003-3489-6426
Manish Kumar GuptaSGT College of Pharmacy, SGT University, Gurugram 122505, Haryana, India.
Energy and Resources Institute · INSerdia Pharmaceuticals (India) · INShree Guru Gobind Singh Tricentenary University · INSwami Keshwanand Rajasthan Agricultural University · INThapar Institute of Engineering & Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

Indexed as

AMRantibacterial compounddrug resistanceendophytic fungimedicinal plantnatural product

Identifiers

PMID35205918
PMCPMC8877021
OpenAlexW4211122881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.