Evidence map›Paper›PMID 35205781›Full record

ArticleCancers2022

Proliferative Potential, and Inflammatory Tumor Microenvironment in Meningioma Correlate with Neurological Function at Presentation and Anatomical Location-From Convexity to Skull Base and Spine.

Johannes Wach, Tim Lampmann, Ági Güresir, Hartmut Vatter, Ulrich Herrlinger, Albert Becker, Silvia Cases-Cunillera, Michael Hölzel, Marieta Toma, Erdem Güresir

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Johannes WachDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-4680-0412
Tim LampmannDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Ági GüresirDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Hartmut VatterDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Ulrich HerrlingerDivision of Clinical Neurooncology, Department of Neurology, University Hospital Bonn, 53127 Bonn, Germany.
Albert BeckerDepartment of Neuropathology, University Hospital Bonn, 53127 Bonn, Germany.
Silvia Cases-CunilleraDepartment of Neuropathology, University Hospital Bonn, 53127 Bonn, Germany.
Michael HölzelInstitute of Experimental Oncology, University Hospital Bonn, 53127 Bonn, Germany.
Marieta TomaInstitute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Erdem GüresirDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0001-8319-0847
University Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence emphasizes the prognostic importance of meningioma location. The present investigation evaluates whether progression-free survival (PFS), proliferative potential, World Health Organization (WHO) grades, and inflammatory burden differ between anatomical locations (skull base, non-skull base, and spinal) meningiomas. Five-hundred-forty-one patients underwent Simpson grade I or II resection for WHO grade 1 or 2 meningiomas. Univariable analysis revealed that spinal meningioma patients are significantly older, had a worse baseline Karnofsky Performance Status (KPS), higher acute-phase protein levels, lower incidence of WHO grade 2, lower mitotic counts, lower MIB-1 index, and less CD68

Indexed as

anatomic locationmacrophagesmeningiomaMIB-1 indextumor progression

Identifiers

PMID35205781
PMCPMC8870248
OpenAlexW4213135265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.