Evidence map›Paper›PMID 35205746›Full record

ArticleCancers2022

Non-Invasive Monitoring of Increased Fibrotic Tissue and Hyaluronan Deposition in the Tumor Microenvironment in the Advanced Stages of Pancreatic Ductal Adenocarcinoma.

Ravneet Vohra, Yak-Nam Wang, Helena Son, Stephanie Totten, Akshit Arora, Adam Maxwell, Donghoon Lee

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ravneet VohraDepartment of Radiology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0001-6258-2710
Yak-Nam WangApplied Physics Laboratory, University of Washington, Seattle, WA 98105, USA.
Helena SonDivision of Gastroenterology, University of Washington, Seattle, WA 98104, USA.
Stephanie TottenDivision of Gastroenterology, University of Washington, Seattle, WA 98104, USA.
Akshit AroraDepartment of Art and Sciences, University of Washington, Seattle, WA 98195, USA.
Adam MaxwellDepartment of Urology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Donghoon LeeDepartment of Radiology, University of Washington, Seattle, WA 98109, USA.
University of Washington · USUniversity of Washington Applied Physics Laboratory · US

Funding

MR-HIFU induced drug delivery for pancreatic cancer treatmentR01CA188654 · NCI · UNIVERSITY OF WASHINGTON · PI LEE, DONGHOON · 2015 to 2019
$2.6M
NCI NIH HHS R01 CA188654NIH HHS R01 CA188654
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinomas are characterized by a complex and robust tumor microenvironment (TME) consisting of fibrotic tissue, excessive levels of hyaluronan (HA), and immune cells. We utilized quantitative multi-parametric magnetic resonance imaging (mp-MRI) methods at 14 Tesla in a genetically engineered KPC (

Indexed as

amide proton transfer (APT)apparent diffusion coefficient (ADC)chemical exchange saturation transfer (CEST)glycosaminoglycan (Gag)multi-parametric magnetic resonance imaging (mp-MRI)pancreatic ductal adenocarcinoma (PDAC)

Identifiers

PMID35205746
PMCPMC8870395
OpenAlexW4212949420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.