ArticleProceedings of the National Academy of Sciences of the United States of America1986
High content of creatine kinase in chicken retina: compartmentalized localization of creatine kinase isoenzymes in photoreceptor cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 77 citations in OpenAlex.
- Rapid LC-MS/MS Method for Targeted Assay of Creatine Deficiency Syndromes in Morocco.Metabolites · 2026Article
- Evidence of Oxidative Phosphorylation in Zebrafish Photoreceptor Outer Segments at Different Larval Stages.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Interactome Mapping Guided by Tissue-Specific Phosphorylation in Age-Related Macular Degeneration.International journal of scientific and engineering research · 2017Article
- The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases.Molecular vision · 2016Article
- Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.The Journal of clinical investigation · 2012Article
- Review
- The creatine kinase system and pleiotropic effects of creatine.Amino acids · 2011Review
- Flow of energy in the outer retina in darkness and in light.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Proteomics of photoreceptor outer segments identifies a subset of SNARE and Rab proteins implicated in membrane vesicle trafficking and fusion.Molecular & cellular proteomics : MCP · 2008Article
- The evolution of eukaryotic cilia and flagella as motile and sensory organelles.Advances in experimental medicine and biology · 2007Review
- ATP production in Chlamydomonas reinhardtii flagella by glycolytic enzymes.Molecular biology of the cell · 2005Article
- Oral creatine supplementation and skeletal muscle metabolism in physical exercise.Sports medicine (Auckland, N.Z.) · 2002Review
- Kinetics of oxygen consumption and light-induced changes of nucleotides in solitary rod photoreceptors.The Journal of general physiology · 1996Article
- Co-localization and functional coupling of creatine kinase B and gastric H+/K(+)-ATPase on the apical membrane and the tubulovesicular system of parietal cells.The Biochemical journal · 1995Article
- Tissue- and cell-specific distribution of creatine kinase B: a new and highly specific monoclonal antibody for use in immunohistochemistry.Cell and tissue research · 1995Article
- In situ compartmentation of creatine kinase in intact sarcomeric muscle: the acto-myosin overlap zone as a molecular sieve.Journal of muscle research and cell motility · 1992Article
- Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis.The Biochemical journal · 1992Review
- Localization of brain type creatine kinase in kidney epithelial cell subpopulations in rat.Experientia · 1988Article
- Creatine kinase in non-muscle tissues and cells.Molecular and cellular biochemistryReview
- Creatine metabolism and the consequences of creatine depletion in muscle.Molecular and cellular biochemistryReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two isoforms of creatine kinase (CK; ATP:creatine N-phosphotransferase, E.C. 2.7.3.2), brain type (BB-CK) and mitochondrial type (MiMi-CK), but not the muscle types (MM- or hybrid MB-CK), were identified by cellulose polyacetate electrophoresis and immunoblots in retina from adult chickens. Indirect immunofluorescence labeling of cryosections of retinas revealed high concentrations of BB-CK in both rod and cone photoreceptor cells. Most of the fluorescence staining with anti-B-CK antibodies was found within the myoid and the ellipsoid portions of inner segments and the peripheral region of the outer segments. Significant staining with anti-B-CK antibodies was also found in horizontal cells and in the optical nerve fibers, with additional stratified staining in the inner plexiform layer. MiMi-CK was solely demonstrated in the ellipsoid portion of the photoreceptor cells. The presence of high concentrations of compartmentalized CK isoenzymes within photoreceptor cells (approximately equal to 30 enzyme units/mg) as well as the relatively high concentration of total creatine in these cells (approximately equal to 10-15 mM) indicates an important physiological function for CK and phosphocreatine in the energy transduction of vision.
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Registered trials
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