Evidence map›Paper›PMID 35205422›Full record

ArticleGenes2022

Saqib Hassan, Marika A Kaakinen, Harmen Draisma, Liudmila Zudina, Mohd A Ganie, Aafia Rashid, Zhanna Balkhiyarova, George S Kiran, Paris Vogazianos, Christos Shammas and 4 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 5 countries.

Saqib HassanSection of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0001-7912-1865
Marika A KaakinenSection of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
Harmen DraismaSection of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
Liudmila ZudinaSection of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK.
Mohd A GanieDepartment of Endocrinology, Sheri-Kashmir Institute of Medical Sciences (SKIMS), Srinagar 190011, India.ORCID 0000-0002-7649-6749
Aafia RashidDepartment of Endocrinology, Sheri-Kashmir Institute of Medical Sciences (SKIMS), Srinagar 190011, India.
Zhanna BalkhiyarovaSection of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
George S KiranDepartment of Food Science and Technology, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
Paris VogazianosStremble Ventures Ltd., Limassol 4710, Cyprus.ORCID 0000-0001-9991-6059
Christos ShammasAVVA Pharmaceuticals Ltd., Limassol 4710, Cyprus.ORCID 0000-0001-7295-6587
Joseph SelvinDepartment of Microbiology, School of Life Sciences, Pondicherry University, Puducherry 605014, India.ORCID 0000-0001-9292-8145
Athos AntoniadesStremble Ventures Ltd., Limassol 4710, Cyprus.ORCID 0000-0002-5789-5103
Ayse DemirkanSection of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK.
Inga ProkopenkoSection of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0003-1624-7457
University of Surrey · GBPondicherry University · INSher-i-Kashmir Institute of Medical Sciences · INCentre National de la Recherche Scientifique · FRLimassol General Hospital · CYUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a very common endocrine condition in women in India. Gut microbiome alterations were shown to be involved in PCOS, yet it is remarkably understudied in Indian women who have a higher incidence of PCOS as compared to other ethnic populations. During the regional PCOS screening program among young women, we recruited 19 drug naive women with PCOS and 20 control women at the Sher-i-Kashmir Institute of Medical Sciences, Kashmir, North India. We profiled the gut microbiome in faecal samples by 16S rRNA sequencing and included 40/58 operational taxonomic units (OTUs) detected in at least 1/3 of the subjects with relative abundance (RA) ≥ 0.1%. We compared the RAs at a family/genus level in PCOS/non-PCOS groups and their correlation with 33 metabolic and hormonal factors, and corrected for multiple testing, while taking the variation in day of menstrual cycle at sample collection, age and BMI into account. Five genera were significantly enriched in PCOS cases:

Indexed as

Gastrointestinal MicrobiomePolycystic Ovary SyndromeBacteroidetesBifidobacteriumFecesFemaleHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16Samenorrheaendocrinegut microbiomehormoneIndian populationPCOS

Identifiers

PMID35205422
PMCPMC8871983
OpenAlexW4220652209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.