Evidence map›Paper›PMID 35205397›Full record

ArticleGenes2022

Latent Membrane Protein 1 (LMP1) from Epstein-Barr Virus (EBV) Strains M81 and B95.8 Modulate miRNA Expression When Expressed in Immortalized Human Nasopharyngeal Cells.

Barbara G Müller Coan, Ethel Cesarman, Marcio Luis Acencio, Deilson Elgui de Oliveira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Barbara G Müller CoanBiosciences Institute of Botucatu, São Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.ORCID 0000-0002-6178-2099
Ethel CesarmanDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Marcio Luis AcencioLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, L-4367 Luxembourg, Luxembourg.ORCID 0000-0002-8278-240X
Deilson Elgui de OliveiraDepartment of Pathology, Medical School, São Paulo State University (UNESP), Botucatu, SP, 18618-687, Brazil.ORCID 0000-0001-5562-9648
Universidade Estadual Paulista (Unesp) · BRCornell University · USUniversity of Luxembourg · LU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Epstein-Barr virus (EBV) is a ubiquitous γ herpesvirus strongly associated with nasopharyngeal carcinomas, and the viral oncogenicity in part relies on cellular effects of the viral latent membrane protein 1 (LMP1). It was previously described that EBV strains B95.8 and M81 differ in cell tropism and the activation of the lytic cycle. Nonetheless, it is unknown whether LMP1 from these strains have different effects when expressed in nasopharyngeal cells. Thus, herein we evaluated the effects of EBV LMP1 derived from viral strains B95.8 and M81 and expressed in immortalized nasopharyngeal cells NP69

Indexed as

Epstein-Barr Virus InfectionsMicroRNAsNasopharyngeal NeoplasmsHerpesvirus 4, HumanHumansMembrane ProteinsViral ProteinsMembrane ProteinsMicroRNAsViral ProteinsEBVexpression profilingLMP1microRNAsnasopharyngeal cells

Identifiers

PMID35205397
PMCPMC8871543
OpenAlexW4212800051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.