Evidence map›Paper›PMID 35205323›Full record

ArticleGenes2022

Subcellular Dynamics of a Conserved Bacterial Polar Scaffold Protein.

Giacomo Giacomelli, Helge Feddersen, Feng Peng, Gustavo Benevides Martins, Manuela Grafemeyer, Fabian Meyer, Benjamin Mayer, Peter L Graumann, Marc Bramkamp

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. The polar landscape of bacterial pathogens and predators.Current opinion in microbiology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Altered cell length in deletion mutants of the different divIVA genes in Rhodococcus erythropolis PR4.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The roles of GpsB and DivIVA inFrontiers in microbiology · 2023
    Article
  13. Article
  14. Article
  15. Insights Into the Helical Shape Complex ofFrontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Giacomo GiacomelliInstitute for General Microbiology, Christian-Albrechts-University Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.
Helge FeddersenInstitute for General Microbiology, Christian-Albrechts-University Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.
Feng PengInstitute for General Microbiology, Christian-Albrechts-University Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.
Gustavo Benevides MartinsFaculty of Biology, Ludwig-Maximilians-University Munich, Großhaderner Straße 2-4, 82152 Planegg-Martinsried, Germany.
Manuela GrafemeyerInstitute for General Microbiology, Christian-Albrechts-University Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.ORCID 0000-0003-3474-5222
Fabian MeyerInstitute for General Microbiology, Christian-Albrechts-University Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.
Benjamin MayerSYNMIKRO, LOEWE-Zentrum für Synthetische Mikrobiologie, Karl von Frisch Straße 14, D-35043 Marburg, Germany.ORCID 0000-0001-6889-3210
Peter L GraumannSYNMIKRO, LOEWE-Zentrum für Synthetische Mikrobiologie, Karl von Frisch Straße 14, D-35043 Marburg, Germany.
Marc BramkampInstitute for General Microbiology, Christian-Albrechts-University Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.
Christian-Albrechts-Universität zu Kiel · DEPhilipps University of Marburg · DELudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to survive, bacterial cells rely on precise spatiotemporal organization and coordination of essential processes such as cell growth, chromosome segregation, and cell division. Given the general lack of organelles, most bacteria are forced to depend on alternative localization mechanisms, such as, for example, geometrical cues. DivIVA proteins are widely distributed in mainly Gram-positive bacteria and were shown to bind the membrane, typically in regions of strong negative curvature, such as the cell poles and division septa. Here, they have been shown to be involved in a multitude of processes: from apical cell growth and chromosome segregation in actinobacteria to sporulation and inhibition of division re-initiation in firmicutes. Structural analyses revealed that DivIVA proteins can form oligomeric assemblies that constitute a scaffold for recruitment of other proteins. However, it remained unclear whether interaction with partner proteins influences DivIVA dynamics. Using structured illumination microscopy (SIM), single-particle tracking (SPT) microscopy, and fluorescent recovery after photobleaching (FRAP) experiments, we show that DivIVA from

Indexed as

Bacterial ProteinsCell Cycle ProteinsBacillus subtilisCell DivisionChromosome SegregationBacterial ProteinsCell Cycle ProteinsBacillusCorynebacteriumDivIVAMinJParBsingle-molecule localization microscopy

Identifiers

PMID35205323
PMCPMC8872289
OpenAlexW4210693766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.