Evidence map›Paper›PMID 35205250›Full record

ArticleGenes2022

Stability and Oligomerization of Mutated SMN Protein Determine Clinical Severity of Spinal Muscular Atrophy.

Emma Tabe Eko Niba, Hisahide Nishio, Yogik Onky Silvana Wijaya, Mawaddah Ar Rochmah, Toru Takarada, Atsuko Takeuchi, Tomokazu Kimizu, Kentaro Okamoto, Toshio Saito, Hiroyuki Awano and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Single NucleotideNeurology. Genetics · 2025
    Article
  2. [Research progress on phenotypic modifier genes in spinal muscular atrophy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Emma Tabe Eko NibaDepartment of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan.ORCID 0000-0002-1311-3448
Hisahide NishioDepartment of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan.ORCID 0000-0002-6778-4511
Yogik Onky Silvana WijayaDepartment of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan.ORCID 0000-0001-8066-9211
Mawaddah Ar RochmahDepartment of Neurology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Jalan Farmako, Sekip Utara, Yogyakarta 55281, Indonesia.
Toru TakaradaLaboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Hyogo, Japan.ORCID 0000-0001-9993-4433
Atsuko TakeuchiInstrumental Analysis Center, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Hyogo, Japan.ORCID 0000-0001-7841-2783
Tomokazu KimizuDepartment of Pediatric Neurology, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi 594-1101, Osaka, Japan.ORCID 0000-0003-2809-4670
Kentaro OkamotoDepartment of Pediatrics, Ehime Prefectural Imabari Hospital, 4-5-5 Ishii-cho, Imabari 794-0006, Ehime, Japan.ORCID 0000-0001-5677-4222
Toshio SaitoDepartment of Neurology, National Hospital Organization Osaka Toneyama Medical Center, 5-1-1 Toneyama, Toyonaka 560-8552, Osaka, Japan.
Hiroyuki AwanoDepartment of Pediatrics, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan.ORCID 0000-0001-9846-4142
Yasuhiro TakeshimaDepartment of Pediatrics, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Hyogo, Japan.ORCID 0000-0002-6468-7185
Masakazu ShinoharaDepartment of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan.
Kobe University · JPKobe Pharmaceutical University · JPEhime Prefectural Central Hospital · JPHyogo Medical University · JPKobe Gakuin University · JPOsaka Women's and Children's Hospital · JPToneyama National Hospital · JPUniversitas Gadjah Mada · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal muscular atrophy (SMA) is a common autosomal recessive neuromuscular disease characterized by defects of lower motor neurons. Approximately 95% of SMA patients are homozygous for

Indexed as

Muscular Atrophy, SpinalSurvival of Motor Neuron 1 ProteinDNA, ComplementaryHeLa CellsHomozygoteHumansMutationDNA, ComplementarySMN1 protein, humanSurvival of Motor Neuron 1 Proteinmutated SMN1 proteinoligomerizationSMAstability

Identifiers

PMID35205250
PMCPMC8872419
OpenAlexW4210715411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.