Evidence map›Paper›PMID 35205244›Full record

ArticleGenes2022

"Silicon-On-Insulator"-Based Nanosensor for the Revelation of MicroRNA Markers of Autism.

Yuri D Ivanov, Kristina A Malsagova, Kristina V Goldaeva, Tatyana O Pleshakova, Ivan D Shumov, Rafael A Galiullin, Svetlana I Kapustina, Ivan Y Iourov, Svetlana G Vorsanova, Stepan V Ryabtsev and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Yuri D IvanovInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.
Kristina A MalsagovaInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.ORCID 0000-0001-9404-1660
Kristina V GoldaevaInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.ORCID 0000-0002-4082-1247
Tatyana O PleshakovaInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.
Ivan D ShumovInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.ORCID 0000-0002-9795-7065
Rafael A GaliullinInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.
Svetlana I KapustinaInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.
Ivan Y IourovMental Health Research Center, 117152 Moscow, Russia.ORCID 0000-0002-4134-8367
Svetlana G VorsanovaVeltischev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Taldomskaya St. 2, 125412 Moscow, Russia.
Stepan V RyabtsevCenter for Research of Social Systems, 354340 Sochi, Russia.
Vladimir P PopovRzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-7415-1405
Alexander I ArchakovInstitute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.
Institute of Biomedical Chemistry · RUMental Health Research Center of Russian Academy of Medical Sciences · RUPirogov Russian National Research Medical University · RURussian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs), which represent short (20 to 22 nt) non-coding RNAs, were found to play a direct role in the development of autism in children. Herein, a highly sensitive "silicon-on-insulator"-based nanosensor (SOI-NS) has been developed for the revelation of autism-associated miRNAs. This SOI-NS comprises an array of nanowire sensor structures fabricated by complementary metal-oxide-semiconductor (CMOS)-compatible technology, gas-phase etching, and nanolithography. In our experiments described herein, we demonstrate the revelation of ASD-associated miRNAs in human plasma with the SOI-NS, whose sensor elements were sensitized with oligonucleotide probes. In order to determine the concentration sensitivity of the SOI-NS, experiments on the detection of synthetic DNA analogues of autism-associated miRNAs in purified buffer were performed. The lower limit of miRNA detection attained in our experiments amounted to 10

Indexed as

Autistic DisorderBiosensing TechniquesMicroRNAsNanowiresBiomarkersChildHumansSiliconBiomarkersMicroRNAsSiliconautismmicroRNAnanosensornucleic acid detection

Identifiers

PMID35205244
PMCPMC8872218
OpenAlexW4206986216

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.