Evidence map›Paper›PMID 35205228›Full record

ArticleGenes2022

Evolutionary Genetic Signatures of Selection on Bone-Related Variation within Human and Chimpanzee Populations.

Daryn A Stover, Genevieve Housman, Anne C Stone, Michael S Rosenberg, Brian C Verrelli

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Genome-wide parallelism underlies contemporary adaptation in urban lizards.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Daryn A StoverSchool of Life Sciences, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-4768-6308
Genevieve HousmanSection of Genetic Medicine, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-3482-7511
Anne C StoneSchool of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0001-8021-8314
Michael S RosenbergCenter for Biological Data Science, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0001-7882-2467
Brian C VerrelliSchool of Life Sciences, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-9670-4920
Arizona State University · USVirginia Commonwealth University · USUniversity of Chicago · US

Funding

eQTL mapping in response to osteoarthritis induction in differentiated skeletal cell typesF32AR075397 · NIAMS · UNIVERSITY OF CHICAGO · PI HOUSMAN, GENEVIEVE · 2020 to 2022
$189k
NIAMS NIH HHS F32 AR075397
6 · The paper itself

Abstract

Bone strength and the incidence and severity of skeletal disorders vary significantly among human populations, due in part to underlying genetic differentiation. While clinical models predict that this variation is largely deleterious, natural population variation unrelated to disease can go unnoticed, altering our perception of how natural selection has shaped bone morphologies over deep and recent time periods. Here, we conduct the first comparative population-based genetic analysis of the main bone structural protein gene, collagen type I α 1 (

Indexed as

Bone and BonesGenetic VariationPan troglodytesAnimalsBiological EvolutionCollagen Type I, alpha 1 ChainGenetics, PopulationHumansSelection, GeneticCOL1A1 protein, humanCollagen Type I, alpha 1 ChainadaptationBMDbone diseaseCOL1A1exon duplicationosteoporosistype I collagen

Identifiers

PMID35205228
PMCPMC8871609
OpenAlexW4206969783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.