Evidence map›Paper›PMID 35204828›Full record

ArticleBiomolecules2022

Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients.

Arianna De Rosa, Anna Di Maio, Silvia Torretta, Martina Garofalo, Valentina Giorgelli, Rita Masellis, Tommaso Nuzzo, Francesco Errico, Alessandro Bertolino, Srinivasa Subramaniam and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Arianna De RosaLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.ORCID 0000-0003-4985-1677
Anna Di MaioLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Silvia TorrettaGroup of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy.
Martina GarofaloLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Valentina GiorgelliGroup of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy.
Rita MasellisGroup of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-4817-3707
Tommaso NuzzoLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Francesco ErricoLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.ORCID 0000-0002-3636-7395
Alessandro BertolinoGroup of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy.
Srinivasa SubramaniamDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Antonio RampinoGroup of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-9654-3266
Alessandro UsielloLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Ceinge Biotecnologie Avanzate (Italy) · ITUniversity of Bari Aldo Moro · ITUniversity of Campania "Luigi Vanvitelli" · ITAzienda Universitaria Ospedaliera Consorziale - Policlinico Bari · ITScripps Research Institute · US

Funding

ROLE OF PROGESTERONE RECEPTOR RATIO IN BREAST CANCERF32CA090073 · NCI · UNIVERSITY OF COLORADO DENVER · PI JACOBSEN, BRITTA M · 2001 to 2003
$127k
NCI NIH HHS F32 CA090073
6 · The paper itself

Abstract

Schizophrenia (SCZ) is a polygenic severe mental illness. Genome-wide association studies (GWAS) have detected genomic variants associated with this psychiatric disorder and pathway analyses have indicated immune system and dopamine signaling as core components of risk in dorsolateral-prefrontal cortex (DLPFC) and hippocampus, but the mechanistic links remain unknown. The

Indexed as

DNA-Binding ProteinsGuanine Nucleotide Exchange FactorsSchizophreniaBrainDopamineGenome-Wide Association StudyHumansPrefrontal CortexSerumDNA-Binding ProteinsDopamineGuanine Nucleotide Exchange FactorsRASGRP1 protein, humanDLPFChippocampusRasGRP1schizophreniaserum

Identifiers

PMID35204828
PMCPMC8869509
OpenAlexW4213027691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.