Evidence map›Paper›PMID 35204613›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria.

Bernard Tornyigah, Samuel Odarkwei Blankson, Rafiou Adamou, Azizath Moussiliou, Lauriane Rietmeyer, Patrick Tettey, Liliane Dikroh, Bernard Addo, Helena Lamptey, Maroufou J Alao and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Observational
  3. suPAR to Risk-Stratify Patients With Malaria.Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Bernard TornyigahUniversité de Paris, MERIT, IRD, 75006 Paris, France.
Samuel Odarkwei BlanksonUniversité de Paris, MERIT, IRD, 75006 Paris, France.ORCID 0000-0002-8963-6595
Rafiou AdamouInstitut de Recherche Clinique du Benin (IRCB), Calavi, Benin.
Azizath MoussiliouInstitut de Recherche Clinique du Benin (IRCB), Calavi, Benin.
Lauriane RietmeyerUniversité de Paris, MERIT, IRD, 75006 Paris, France.
Patrick TetteyDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.ORCID 0000-0002-6060-9497
Liliane DikrohDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.ORCID 0000-0003-4201-2133
Bernard AddoDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Helena LampteyDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.ORCID 0000-0002-6426-6540
Maroufou J AlaoDépartement de Pédiatrie, Hôpital Mère-Enfant la Lagune (CHUMEL), Cotonou, Benin.
Annick AmoussouService de Pédiatrie, Centre Hospitalo-Universitaire, Suruléré (CHU-Suruléré), Cotonou, Benin.
Caroline PadounouCentre Hospitalier Universitaire de l'Oueme/Plateau, Porto-Novo, Benin.
Christian RoussilhonUnité de Génétique Fonctionnelle des Maladies Infectieuses, Département Génomes et Génétique, Institut Pasteur, 28 Rue du Docteur Roux, 75015 Paris, France.
Sylvie PonsLaboratoire Commun de Recherche Hospices Civils de Lyon-BioMérieux, Centre Hospitalier Lyon-Sud, Bâtiment 3F, 165 chemin du Grand Revoyet, 69310 Pierre-Bénite, France.
Benedicta Ayiedu MensahDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Nicaise Tuikue NdamUniversité de Paris, MERIT, IRD, 75006 Paris, France.
Rachida TaharUniversité de Paris, MERIT, IRD, 75006 Paris, France.ORCID 0000-0003-1799-231X
University of Ghana · GHCentre National Hospitalier et Universitaire Hubert Koutoukou MAGA · BJHôpital Mère-Enfant · FRHospices Civils de Lyon · FRInstitut Pasteur · FRUniversité Paris Cité · FR

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
FIC NIH HHS D43 TW010540Institut de Recherche pour le Développement No numberInstitut Mérieux (France) No numberSCAC- Cultural and Cooperation Department - French Embassy in Ghana No numberThe Danish International Development Agency (DANIDA) No number
6 · The paper itself

Abstract

Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (

Indexed as

Ang-2biomarkerscerebral malariaEPCRPCTPTX3sICAM-1sTie-2suPAR

Identifiers

PMID35204613
PMCPMC8871337
OpenAlexW4213045447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.