Evidence map›Paper›PMID 35204554›Full record

ReviewDiagnostics (Basel, Switzerland)2022

Lanthanum Carbonate Opacities-A Systematic Review.

Jan Kampmann, Nina Pirschel Hansen, Anders Nikolai Ørsted Schultz, Andreas Hjelm Brandt, Frans Brandt

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jan KampmannMedical Research Unit, Department of Internal Medicine, Hospital of Southern Jutland, 6200 Aabenraa, Denmark.ORCID 0000-0002-8844-8242
Nina Pirschel HansenDepartment of Radiology, Hospital of Southern Jutland, Aabenraa Branch, 6200 Aabenraa, Denmark.
Anders Nikolai Ørsted SchultzMedical Research Unit, Department of Internal Medicine, Hospital of Southern Jutland, 6200 Aabenraa, Denmark.ORCID 0000-0002-1908-6428
Andreas Hjelm BrandtDepartment of Radiology, Rigshospitalet, 2100 Copenhagen, Denmark.
Frans BrandtMedical Research Unit, Department of Internal Medicine, Hospital of Southern Jutland, 6200 Aabenraa, Denmark.
University of Southern Denmark · DKRigshospitalet · DKSygehus Sønderjylland · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLanthanum carbonate is a phosphate binder used in advanced kidney disease. Its radiopaque appearance has been described in many case studies and case series. Misinterpretation of this phenomenon leads to unnecessary diagnostic tests and procedures. The objectives of this study were to summarize the literature on lanthanum carbonate opacities and present a visual overview.

methodsA systematic search was conducted using MEDLINE, Embase, and Web of Science. We included all types of studies, including case reports/studies, describing radiological findings of lanthanum carbonate opacities in patients with chronic kidney disease. No filter for time was set.

resultsA total of 36 articles were eligible for data extraction, and 33 articles were included in the narrative synthesis. Lanthanum carbonate opacities were most commonly reported in the intestines (26 studies, 73%), stomach (8 studies, 21%), and the aerodigestive tract (2 studies, 6%). The opacities in the intestine were most frequently described as multiple, scattered radiopaque densities, compared with the aerodigestive tract, where the opacities were described as a single, round foreign body. Suspicion of contrast medium or foreign bodies was the most common differential diagnosis. LC opacities in patients with CKD are commonly misinterpreted as foreign bodies or suspect contrast media.

conclusionsCKD patients treated with LC may have opacities throughout the digestive tract that can vary in appearance. Stopping LC treatment or changing to an alternative phosphate binder prior to planned image studies can avoid diagnostic confusion. If this is not an option, knowledge of the presentation of LC opacities is important.

Indexed as

CKDimage studieslanthanum carbonate

Identifiers

PMID35204554
PMCPMC8871341
OpenAlexW4212889557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.