Evidence map›Paper›PMID 35204398›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Blood Levels of Indicators of Lower Respiratory Tract Damage in Chronic Bronchitis in Patients with Abdominal Obesity.

Elena V Kashtanova, Yana V Polonskaya, Evgeniia V Striukova, Liliia V Shcherbakova, Evgenii A Kurtukov, Viktoriya S Shramko, Ekaterina M Stakhneva, Yulia I Ragino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Elena V KashtanovaResearch Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia.ORCID 0000-0003-2268-4186
Yana V PolonskayaResearch Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia.ORCID 0000-0002-3538-0280
Evgeniia V StriukovaResearch Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia.ORCID 0000-0001-5316-4664
Liliia V ShcherbakovaResearch Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia.
Evgenii A KurtukovResearch Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia.
Viktoriya S ShramkoResearch Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia.ORCID 0000-0002-0436-2549
Ekaterina M StakhnevaResearch Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia.ORCID 0000-0003-0484-6540
Yulia I RaginoResearch Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia.ORCID 0000-0002-4936-8362
Institute of Cytology and Genetics · RU

Funding

RSF 21-15-00022
6 · The paper itself

Abstract

objectiveto study biomolecules associated with pathology in the respiratory system, in particular, with the development of chronic bronchitis in patients with abdominal obesity. MATERIALS AND

methodsThis is a pilot study. The main group consisted of 158 people with chronic bronchitis, divided into two subgroups: one with abdominal obesity, and the other without it. The control group consisted of 68 people without chronic bronchitis. We determined the blood levels of SP-A, SP-D, α1-antitrypsin, CC16, PARC, and RELM-β.

resultsIn the first subgroup, patients significantly more often complained of coughing, experienced shortness of breath 1.5 times more often with light physical exertion and 2.7 times more often with moderate physical exertion. In these patients, a Tiffeneau-Pinelli index (FEV1/FVC) below 70% was 1.8 times more common, more patients had FEV1 and FVC of less than 80%, and presented a statistically significant decrease in SP-A, α1-antitrypsin, CC16 levels and an increase in PARC levels than in the second subgroup.

conclusionIn patients with chronic bronchitis and abdominal obesity, there is a decrease in the levels of SP-A, α1-antitrypsin, CC16 and an increase in the level of PARC compared with patients without abdominal obesity, which is probably due to the presence of an additional source of chronic inflammation associated with adipose tissue.

Indexed as

abdominal obesityCC16chronic bronchitisPARCRELM-βSP-ASP-Dα1-antitrypsin

Identifiers

PMID35204398
PMCPMC8870849
OpenAlexW4210487823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.