Evidence map›Paper›PMID 35204381›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed-Sternberg-like Cells.

Arianna Di Napoli, Evelina Rogges, Niccolò Noccioli, Anna Gazzola, Gianluca Lopez, Severino Persechino, Rita Mancini, Elena Sabattini

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Arianna Di NapoliDepartment of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University, 00189 Rome, Italy.ORCID 0000-0002-3159-5380
Evelina RoggesDepartment of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University, 00189 Rome, Italy.
Niccolò NoccioliDepartment of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University, 00189 Rome, Italy.
Anna GazzolaHaematopathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy.
Gianluca LopezDepartment of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University, 00189 Rome, Italy.
Severino PersechinoNESMOS Department, Dermatology Unit, Sant'Andrea Hospital, Sapienza University, 00189 Rome, Italy.
Rita ManciniDepartment of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University, 00189 Rome, Italy.
Elena SabattiniHaematopathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-4136-3591
Azienda Ospedaliera Sant'Andrea · ITAzienda USL di Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spectrum of cutaneous CD30-positive lymphoproliferative disorders encompasses both inflammatory and neoplastic conditions. CD30+ Hodgkin and Reed-Sternberg-like cells have been occasionally reported in primary cutaneous marginal zone lymphoma, where they are thought to represent a side neoplastic component within a dominant background of lymphomatous small B cells. Herein, we describe the histological and molecular findings of three cases of primary cutaneous marginal zone lymphomas with CD30+ H/RS cells, in which next-generation sequencing analysis revealed the clonal population to consist in less than 5% of the cutaneous B-cell infiltrate, providing a thought-provoking focus on a possible main role for CD30+ cells in primary cutaneous marginal zone lymphoproliferations.

Indexed as

cutaneous marginal zone lymphomaHodgkin and Reed–Stemberg cellsIGH and IGK rearrangementsNGS

Identifiers

PMID35204381
PMCPMC8870847
OpenAlexW4210492049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.