ReviewDiagnostics (Basel, Switzerland)2022
Troponin Cut-Offs for Acute Myocardial Infarction in Patients with Impaired Renal Function-A Systematic Review and Meta-Analysis.
Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A nomogram model for predicting intramyocardial hemorrhage post-PCI based on SYNTAX score and clinical features.BMC cardiovascular disorders · 2024Trial
- Observational
- High Sensitive Cardiac Troponin-I (Hs-cTnI) Levels in Asymptomatic Hemodialysis Patients.Journal of clinical medicine · 2025Article
- Combined prediction value of coronary plaque burden, serum creatinine, MLR and NLR in reinfarction risk after PCI in middle-aged and elderly patients with myocardial infarction.European journal of medical research · 2025Article
- Cardiac Biomarkers Predict Major Adverse Cardiac Events (MACE) in Incident Haemodialysis Patients: Results from a Global Federated Database.Biomedicines · 2025Article
- Validation and correlation of high-sensitive troponin I and troponin T in the emergency department.BMC cardiovascular disorders · 2024Article
- Kidney function-specific cut-off values of high-sensitivity cardiac troponin T for the diagnosis of acute myocardial infarction.Clinical kidney journal · 2024Article
- The Cardio-Kidney Patient: Epidemiology, Clinical Characteristics and Therapy.Circulation research · 2023Review
- Editorial for Special Issue "Advance in Diagnostic and Management of Ischemic Heart Disease".Diagnostics (Basel, Switzerland) · 2023Article
- A review of cardiac troponin I detection by surface enhanced Raman spectroscopy: Under the spotlight of point-of-care testing.Frontiers in chemistry · 2022Review
- Biomarkers and Predictors of Adverse Cardiovascular Events in Different Stages of Chronic Kidney Disease.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying acute myocardial infarction in patients with renal disease is notoriously difficult, due to atypical presentation and chronically elevated troponin. The aim of this study was to identify a specific troponin T/troponin I cut-off value for diagnosis of acute myocardial infarction in patients with renal impairment via meta-analysis. Two investigators screened 2590 publications from MEDLINE, Embase, PubMed, Web of Science, and the Cochrane library. Only studies that investigated alternative cut-offs according to renal impairment were included. Fifteen articles fulfilled the inclusion criteria. Six studies were combined for meta-analysis. The manufacturer's upper reference level for troponin T is 14 ng/L. Based on the meta-analyses, cut-off values for troponin in patients with renal impairment with myocardial infarction was 42 ng/L for troponin I and 48 ng/L for troponin T. For patients on dialysis the troponin T cut-off is even higher at 239 ng/L. A troponin I cut-off value for dialysis patients could not be established due to lack of data. The 15 studies analyzed showed considerable diversity in study design, study population, and the definition of myocardial infarction. Further studies are needed to define a reliable troponin cut-off value for patients with kidney disease, especially in dialysis patients, and to allow necessary subanalysis.
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