Evidence map›Paper›PMID 35204338›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Reliability as a Precondition for Trust-Segmentation Reliability Analysis of Radiomic Features Improves Survival Prediction.

Gustav Müller-Franzes, Sven Nebelung, Justus Schock, Christoph Haarburger, Firas Khader, Federico Pedersoli, Maximilian Schulze-Hagen, Christiane Kuhl, Daniel Truhn

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. A Review of the Role of Ultrasound Radiomics and Its Application and Limitations in the Investigation of Thyroid Disease.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gustav Müller-FranzesDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, 52074 Aachen, Germany.ORCID 0000-0002-7413-2570
Sven NebelungDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, 52074 Aachen, Germany.ORCID 0000-0002-5267-9962
Justus SchockDepartment of Diagnostic and Interventional Radiology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-0512-3053
Christoph HaarburgerDepartment of Research and Development, CheckupPoint GmbH, 81669 Munich, Germany.
Firas KhaderDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, 52074 Aachen, Germany.ORCID 0000-0001-5089-3589
Federico PedersoliDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, 52074 Aachen, Germany.
Maximilian Schulze-HagenDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, 52074 Aachen, Germany.ORCID 0000-0002-9182-2688
Christiane KuhlDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, 52074 Aachen, Germany.
Daniel TruhnDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, 52074 Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Machine learning results based on radiomic analysis are often not transferrable. A potential reason for this is the variability of radiomic features due to varying human made segmentations. Therefore, the aim of this study was to provide comprehensive inter-reader reliability analysis of radiomic features in five clinical image datasets and to assess the association of inter-reader reliability and survival prediction. In this study, we analyzed 4598 tumor segmentations in both computed tomography and magnetic resonance imaging data. We used a neural network to generate 100 additional segmentation outlines for each tumor and performed a reliability analysis of radiomic features. To prove clinical utility, we predicted patient survival based on all features and on the most reliable features. Survival prediction models for both computed tomography and magnetic resonance imaging datasets demonstrated less statistical spread and superior survival prediction when based on the most reliable features. Mean concordance indices were C

Indexed as

inter-rater reliabilityneural networkoverall survivalradiomic featuresrobustnesssegmentation variability

Identifiers

PMID35204338
PMCPMC8871487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.