ArticleAntioxidants (Basel, Switzerland)2022
An Assessment of Cataract Severity Based on Antioxidant Status and Ascorbic Acid Levels in Aqueous Humor.
Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06743594 (Effects of Laser Species and Ocular Antioxidant Activity on Postoperative Inflammation, Oxidative Stress and Visual Prognosis in Patients Undergoing Ophthalmic Surgery - a Comparative Study.), which is not on this map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Laser Species and Ocular Antioxidant Activity on Postoperative Inflammation, Oxidative Stress and Visual Prognosis in Patients Undergoing Ophthalmic Surgery - a Comparative Study.
Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Ultrasound biomicroscopy analysis of age-related trends in lens stability in cortical cataracts.International journal of ophthalmology · 2026Article
- Analysis of Total Antioxidant Capacity and Ascorbic Acid Levels in the Aqueous Humor of Patients With Diabetic Retinopathy.Translational vision science & technology · 2025Article
- Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use-A Prospective Study.Translational vision science & technology · 2025Article
- The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery.Scientific reports · 2025Article
- Article
- Artificial intelligence applications facilitate decision-making in cataract surgery for highly myopic patients.Frontiers in cell and developmental biology · 2025Article
- Trends and hot spots in research related to aqueous humor from 2014 to 2023: A bibliometric analysis.Heliyon · 2024Article
- Protocol for assessing total antioxidant capacity in minimal volumes of varying clinical human samples.STAR protocols · 2024Article
- Differences in change of post-operative antioxidant levels between laser-assisted lenticule extraction and femtosecond laser in situ keratomileusis.Journal of cellular and molecular medicine · 2024Article
- Redox Regulation in Age-Related Cataracts: Roles for Glutathione, Vitamin C, and the NRF2 Signaling Pathway.Nutrients · 2023Review
- Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases.Nutrients · 2023Review
- Chronic Antioxidant Capacity Loss in Anterior Chamber Environment After Iridectomy.Translational vision science & technology · 2023Article
- Potential Properties of Natural Nutraceuticals and Antioxidants in Age-Related Eye Disorders.Life (Basel, Switzerland) · 2022Review
- Zebrafish (Danio rerio) Is an Economical and Efficient Animal Model for Screening Potential Anti-cataract Compounds.Translational vision science & technology · 2022Article
- Ovarian Cancer and the Risk of Cataract Episodes: A Nationwide Cohort Study.In vivo (Athens, Greece)Article
- Postoperative Decline in Antioxidant Concentrations in Aqueous Humor: Comparison Between Femtosecond Laser-assisted Cataract Surgery and Conventional Cataract Surgery.In vivo (Athens, Greece)Article
- The Effect of Preoperative Aqueous Total Antioxidant Capacity on the Postoperative Complications of Cataract Surgery.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Cataract is the leading cause of blindness throughout the world. Currently, the cataract severity evaluation is based on the subjective LOCS III guideline. To ameliorate the evaluation system and develop an objective and quantitative analysis, we investigated the relationships among aqueous humor total antioxidant capacity (AqTAC), ascorbic acid (AqAA) concentration, and cataract severity. In this study, we enrolled 130 cataract patients who underwent phacoemulsification between April 2019 and March 2020. The AqTAC and AqAA were measured by our own developed TAC assay and commercially available kit. Cataract severity was recorded by nuclear opalescence (NO) and cortical cataract (CC) degree according to LOCS III. Cumulative dissipated energy (CDE) during phacoemulsification was recorded to verify the severity of the cataract. As a result, we found a moderate correlation between AqTAC and CDE (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.