Evidence map›Paper›PMID 35204265›Full record

ArticleAntioxidants (Basel, Switzerland)2022

HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation.

Daniele Mancardi, Pasquale Pagliaro, Lisa A Ridnour, Carlo G Tocchetti, Katrina Miranda, Magdalena Juhaszova, Steven J Sollott, David A Wink, Nazareno Paolocci

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Sulfide regulation and catabolism in health and disease.Signal transduction and targeted therapy · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
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  11. Platelets and Cardioprotection: The Role of Nitric Oxide and Carbon Oxide.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Daniele MancardiDepartment of Clinical and Biological Sciences, University of Torino, 1043 Torino, Italy.ORCID 0000-0003-3809-6047
Pasquale PagliaroDepartment of Clinical and Biological Sciences, University of Torino, 1043 Torino, Italy.ORCID 0000-0002-4386-1383
Lisa A RidnourLaboratory of Cancer Immunometabolism, National Cancer Institute, NIH, Frederick, MD 20892, USA.
Carlo G TocchettiCardio-Oncology Unit, Center for Basic and Clinical Immunology (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRI-APA), Department of Translational Medical Sciences, Federico II University, 80131 Napoli, Italy.ORCID 0000-0001-5983-688X
Katrina MirandaDepartment of Chemistry, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-9175-5091
Magdalena JuhaszovaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Steven J SollottLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.ORCID 0000-0003-1730-2956
David A WinkLaboratory of Cancer Immunometabolism, National Cancer Institute, NIH, Frederick, MD 20892, USA.
Nazareno PaolocciDivision of Cardiology, The Johns Medical Institutions, Baltimore, MD 21287, USA.
National Cancer Institute · USNational Institute on Aging · USUniversity of Turin · ITFederico II University Hospital · ITUniversity of Arizona · USUniversity of Padua · IT

Funding

Control Mechanisms for Matching ATP Supply and Demand in Heart MitochondriaZIAAG000250 · NIA · NATIONAL INSTITUTE ON AGING · PI SOLLOTT, STEVEN · 2009 to 2024
$21.0M
CHemical Biology of Nitroxyl (HNO)ZIABC011190 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINK, DAVID · 2009 to 2025
$2.9M
BDNF TrkB- and beta-AR signals in ischemic and non-ischemic cardiomyopathyR01HL136918 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PAOLOCCI, NAZARENO · 2018 to 2021
$2.7M
NIH HHS HHSN261200800001ENIH HHS R01 HL136918
6 · The paper itself

Abstract

Donors of nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO

Indexed as

KATP channelsmitochondrial permeability transition pore (mPTP)myocardial reperfusion injurynitric oxide (NO.)nitroxyl (HNO)PKCε

Identifiers

PMID35204265
PMCPMC8869498
OpenAlexW4213371557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.