Evidence map›Paper›PMID 35204260›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of

Ninon G E R Etsassala, Jelili A Badmus, Jeanine L Marnewick, Samuel Egieyeh, Emmanuel I Iwuoha, Felix Nchu, Ahmed A Hussein

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  6. Hypoglycemic activities of flowers ofChinese herbal medicines · 2024
    Article
  7. Article
  8. Alpha-Glucosidase Inhibitory Activity of Saponins Isolated fromJournal of microbiology and biotechnology · 2023
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ninon G E R EtsassalaDepartment of Horticultural Sciences, Cape Peninsula University of Technology, Symphony Road, Bellville, Cape Town 7535, South Africa.
Jelili A BadmusApplied Microbial and Health Biotechnology Institute, Cape Peninsula University of Technology, Symphony Road, Bellville 7535, South Africa.ORCID 0000-0003-4785-2609
Jeanine L MarnewickApplied Microbial and Health Biotechnology Institute, Cape Peninsula University of Technology, Symphony Road, Bellville 7535, South Africa.ORCID 0000-0002-1819-1699
Samuel EgieyehSchool of Pharmacy, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-7462-6669
Emmanuel I IwuohaChemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.ORCID 0000-0001-6102-0433
Felix NchuDepartment of Horticultural Sciences, Cape Peninsula University of Technology, Symphony Road, Bellville, Cape Town 7535, South Africa.ORCID 0000-0002-9910-5085
Ahmed A HusseinChemistry Department, Cape Peninsula University of Technology, Symphony Road, Bellville 7535, South Africa.ORCID 0000-0002-3877-9959
Cape Peninsula University of Technology · ZAUniversity of the Western Cape · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shortage in insulin secretion or degradation of produced insulin is the principal characteristic of the metabolic disorder of diabetes mellitus (DM). However, because the current medications for the treatment of DM have many detrimental side effects, it is necessary to develop more effective antidiabetic drugs with minimal side effects. Alpha-glucosidase and alpha-amylase inhibitors are directly implicated in the delay of carbohydrate digestion. Pharmacologically, these inhibitors could be targeted for the reduction in glucose absorption rate and, subsequently, decreasing the postprandial rise in plasma glucose and the risk for long-term diabetes complications. The main objectives of this research study were to isolate different phytochemical constituents present in the methanolic extract of

Indexed as

alpha-amylasealpha-glucosidasediabetes mellitusoxidative stressPlectranthus ecklonii

Identifiers

PMID35204260
PMCPMC8869333
OpenAlexW4213291064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.