Evidence map›Paper›PMID 35204223›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Pre-Exposure to Stress-Inducing Agents Increase the Anticancer Efficacy of Focused Ultrasound against Aggressive Prostate Cancer Cells.

Hakm Y Murad, Partha K Chandra, Charles A Kelly, Namrata Khurana, Heng Yu, Emma P Bortz, Shirley N Hong, Debasis Mondal, Damir B Khismatullin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hakm Y MuradDepartment of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA.
Partha K ChandraDepartment of Pharmacology, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-4396-3996
Charles A KellyDepartment of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA.
Namrata KhuranaDepartment of Pharmacology, Tulane University, New Orleans, LA 70112, USA.
Heng YuDepartment of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA.
Emma P BortzDepartment of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA.
Shirley N HongDepartment of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA.
Debasis MondalDepartment of Pharmacology, Tulane University, New Orleans, LA 70112, USA.
Damir B KhismatullinDepartment of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA.
Tulane University · US

Funding

Role of VSMC-Derived Exosomes in the Cardiovascular Complications of DiabetesR01HL127092 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI WOODS, THOMAS COOPER · 2016 to 2019
$1.5M
American Heart Association 13GRNT17200013Louisiana Board of Regents LEQSF (2014-2018)-GF-14National Science Foundation 1438537NIH HHS R01HL127092
6 · The paper itself

Abstract

Despite the initial success in treatment of localized prostate cancer (PCa) using surgery, radiation or hormonal therapy, recurrence of aggressive tumors dictates morbidity and mortality. Focused ultrasound (FUS) is being tested as a targeted, noninvasive approach to eliminate the localized PCa foci, and strategies to enhance the anticancer potential of FUS have a high translational value. Since aggressive cancer cells utilize oxidative stress (Ox-stress) and endoplasmic reticulum stress (ER-stress) pathways for their survival and recurrence, we hypothesized that pre-treatment with drugs that disrupt stress-signaling pathways in tumor cells may increase FUS efficacy. Using four different PCa cell lines, i.e., LNCaP, C4-2B, 22Rv1 and DU145, we tested the

Indexed as

aggressive phenotypeCDDO-mecombined mechanochemical disruptionER-stressfocused ultrasoundnelfinaviroxidative stressprostate cancer

Identifiers

PMID35204223
PMCPMC8868501
OpenAlexW4211003725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.