Evidence map›Paper›PMID 35204187›Full record

ReviewAntioxidants (Basel, Switzerland)2022

How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems.

Yuchen Lei, Yuxiang Huang, Xin Wen, Zhangyuan Yin, Zhihai Zhang, Daniel J Klionsky

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Organelle partitioning in the multi-budding yeastbioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. NADCells · 2025
    Review
  8. Review
  9. Article
  10. Evolutionary conservation and metabolic significance of autophagy in algae.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Yeast Lsm Pro-Apoptotic Mutants Show Defects in Autophagy.International journal of molecular sciences · 2023
    Article
  15. Review
  16. Review
  17. The STAT3-Regulated Autophagy Pathway in Glioblastoma.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuchen LeiLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Yuxiang HuangLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Xin WenLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6513-8623
Zhangyuan YinLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7198-5431
Zhihai ZhangLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel J KlionskyLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7828-8118

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
NIGMS NIH HHS GM131919
6 · The paper itself

Abstract

Eukaryotic cells frequently experience fluctuations of the external and internal environments, such as changes in nutrient, energy and oxygen sources, and protein folding status, which, after reaching a particular threshold, become a type of stress. Cells develop several ways to deal with these various types of stress to maintain homeostasis and survival. Among the cellular survival mechanisms, autophagy is one of the most critical ways to mediate metabolic adaptation and clearance of damaged organelles. Autophagy is maintained at a basal level under normal growing conditions and gets stimulated by stress through different but connected mechanisms. In this review, we summarize the advances in understanding the autophagy regulation mechanisms under multiple types of stress including nutrient, energy, oxidative, and ER stress in both yeast and mammalian systems.

Indexed as

autophagyenergy stressER stressnutrient stressoxidative stressregulation

Identifiers

PMID35204187
PMCPMC8868404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.