ArticleAntioxidants (Basel, Switzerland)2022
Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES).
Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Bio-Nanocomposites Obtained by Green Synthesis with Silver Nanoparticles from By-Products of Fruits, Berries and Vegetables: Structure, Functionality and Applications-A Review.Nanomaterials (Basel, Switzerland) · 2026Review
- Optimization of Onion Peel Bioactive Compounds Using Eco-Friendly Natural Deep Eutectic Solvent Based Ultrasound-Assisted Extraction.Food science & nutrition · 2026Article
- Ultrasound pretreatment enhances drying efficiency and phenolic retention in raspberries during heat pump drying by modulating cell wall structure and water status.Food chemistry: X · 2026Article
- Extraction and Identification of Active Components fromMolecules (Basel, Switzerland) · 2025Article
- Unlocking the potential of plant polyphenols: advances in extraction, antibacterial mechanisms, and future applications.Food science and biotechnology · 2025Review
- Ellagic Acid and Pomegranate (Aquaculture nutrition · 2025Article
- Natural solutions for diabetes: the therapeutic potential of plants and mushrooms.Frontiers in nutrition · 2025Review
- Valorization of Sour Cherry Kernels: Extraction of Polyphenols Using Natural Deep Eutectic Solvents (NADESs).Molecules (Basel, Switzerland) · 2024Article
- A Comprehensive Analysis of Diversity, Structure, Biosynthesis and Extraction of Biologically Active Tannins from Various Plant-Based Materials Using Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2024Review
- Valorisation of Raspberry Seeds in Cosmetic Industry-Green Solutions.Pharmaceutics · 2024Article
- The Effect ofMolecules (Basel, Switzerland) · 2024Article
- Green Extraction of Polyphenols via Deep Eutectic Solvents and Assisted Technologies from Agri-Food By-Products.Molecules (Basel, Switzerland) · 2023Review
- UHPLC-Triple-TOF-MS Characterization, Antioxidant, Antimicrobial and Antiproliferative Activity of Raspberry (Foods (Basel, Switzerland) · 2022Article
- Sustainable Development and Storage Stability of Orange By-Products Extract Using Natural Deep Eutectic Solvents.Foods (Basel, Switzerland) · 2022Article
- Communicating Function and Co-Creating Healthy Food: Designing a Functional Food Product Together with Consumers.Foods (Basel, Switzerland) · 2022Article
- Ultrasound-Assisted Natural Deep Eutectic Solvent Extraction and Bioactivities of Flavonoids inFoods (Basel, Switzerland) · 2022Article
- Natural Deep Eutectic Solvent (NADES) Extraction Improves Polyphenol Yield and Antioxidant Activity of Wild Thyme (Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Defatted raspberry seeds were used as an alternative source of antioxidants and ellagic acid (EA) extracted using Natural deep eutectic solvents (NADES). In the preliminary study, the best NADES combination (citric acid-betaine) and the most influential variables (temperature, time, and NADES/plant ratio) were selected for the further optimization process. All samples were analyzed in terms of total polyphenol, EA content, and antioxidant activity. Two sets of optimal conditions were generated by response surface methodology. The first set (Opt1) was designed for higher conversion of ellagitannins to EA while the latter set (Opt2) for higher EA content/100 g extract. Opt1 and Opt2 had higher values for all investigated responses compared to 80% ethanolic extract but had a lower conversion rate of ellagitannins to EA compared to acidified methanol extract. The third set of parameters (Opt3) selected beyond the initial experimental domain was used to obtain a sample with the highest EA content/100 g extract. Due to their nature, NADES extracts are ready to use and could have various technological roles in products since they are antioxidants, acidifiers, and colorants. NADES raspberry extracts exhibited higher anti-proliferative activity compared to ethanolic extracts in terms of EC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.