ArticleAntioxidants (Basel, Switzerland)2022
Oxidant/Antioxidant Status Is Impaired in Sepsis and Is Related to Anti-Apoptotic, Inflammatory, and Innate Immunity Alterations.
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Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Lycopene Attenuates Acute Cyclophosphamide-Induced Renal Injury in Mice: Renal Function, Cytokine Transcription, and Histopathological Evidence.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Heat Shock Protein 90 in Sepsis-Induced Cardiomyopathy: Mechanistic Insights and Emerging Therapeutic Target.Shock (Augusta, Ga.) · 2026Review
- Care Pathway and Outcomes in Pediatric Septic Shock: A Narrative Review from Emergency Department Recognition to PICU Management.Children (Basel, Switzerland) · 2026Review
- Milk Yield and Quality, Metabolic Profile and Oxidative Status in Lactating Goats, as Affected by Silage Based on Agro-Industrial By-Products.Animals : an open access journal from MDPI · 2026Article
- Plasma, Urinary, and Salivary Total Redox Status in Critically Ill Patients with Brain Injury and Secondary Organ Failure.Antioxidants (Basel, Switzerland) · 2026Article
- Changes in Resveratrol Containing Phytosterol Liposomes During Model Heating.Molecules (Basel, Switzerland) · 2025Article
- Cell-free DNA in sepsis: from molecular insights to clinical management.Military Medical Research · 2025Review
- Quercetin Improves Lipopolysaccharide-Induced Septic Liver Injury by Inhibiting the Activation of ROCK/NF-κB/NLRP3 Pathway.Food science & nutrition · 2025Article
- Necroptotic and Apoptotic Pathways in Sepsis: A Comparative Analysis of Pediatric and Adult ICU Patients.Biomedicines · 2025Article
- In Silico Exploration of Natural Antioxidants for Sepsis Drug Discovery.Molecules (Basel, Switzerland) · 2025Article
- Radiofrequency Electromagnetic and Pulsed Magnetic Fields Protected the Kidney Against Lipopolysaccharide-Induced Acute Systemic Inflammation, Oxidative Stress, and Apoptosis by Regulating the IL-6/HIF1α/eNOS and Bcl2/Bax/Cas-9 Pathways.Medicina (Kaunas, Lithuania) · 2025Article
- Antioxidant Synergy in a Mixture of Powder Plant Leaves and Effects on Metabolic Profile, Oxidative Status and Intestinal Morpho-Histochemical Features of Laying Hens.Animals : an open access journal from MDPI · 2025Article
- Comparison of Oxidative Stress Markers with Clinical Data in Patients Requiring Anesthesia in an Intensive Care Unit.Journal of clinical medicine · 2024Article
- Morin Ameliorates Lipopolysaccharides-Induced Sepsis-Associated Encephalopathy and Cognitive Impairment in Albino Mice.Neurochemical research · 2024Article
- The effects of antioxidant supplementation on short-term mortality in sepsis patients.Heliyon · 2024Article
- Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort study.Frontiers in medicine · 2024Article
- Article
- The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Knockdown of 11β-hydroxysteroid dehydrogenase type 1 alleviates LPS-induced myocardial dysfunction through the AMPK/SIRT1/PGC-1α pathway.Journal of biomedical research · 2023Article
Corrections and comments
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Authors and funding
24 authors at 3 institutions in 1 country.
Marianna MiliarakiPediatric Intensive Care Unit, University Hospital of Heraklion and School of Medicine, University of Crete, 71110 Heraklion, Greece.ORCID 0000-0001-7622-202X
Panagiotis BriassoulisPediatric Intensive Care Unit, University Hospital of Heraklion and School of Medicine, University of Crete, 71110 Heraklion, Greece.
Stavroula IliaPediatric Intensive Care Unit, University Hospital of Heraklion and School of Medicine, University of Crete, 71110 Heraklion, Greece.ORCID 0000-0002-0936-368X
Kalliopi MichalakakouDepartment of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
Theodoros KarakonstantakisDepartment of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
Aikaterini PolonifiFirst Department of Internal Medicine-Propaedeutic, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Kalliopi BastakiPediatric Intensive Care Unit, University Hospital of Heraklion and School of Medicine, University of Crete, 71110 Heraklion, Greece.
Efrossini BriassouliFirst Department of Internal Medicine-Propaedeutic, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Konstantinos VardasFirst Critical Care Department, Evangelismos University Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece.
Aikaterini Pistiki4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Maria Theodorakopoulou2nd Department of Critical Care, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Theonymfi TavladakiPediatric Intensive Care Unit, University Hospital of Heraklion and School of Medicine, University of Crete, 71110 Heraklion, Greece.ORCID 0000-0002-3202-6577
Anna-Maria SpanakiPediatric Intensive Care Unit, University Hospital of Heraklion and School of Medicine, University of Crete, 71110 Heraklion, Greece.
Eumorfia KondiliDepartment of Intensive Care Medicine, University Hospital of Heraklion and Medical School, University of Crete, 71110 Heraklion, Greece.ORCID 0000-0002-3323-5266
Helen DimitriouLaboratory of Child Health, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Maria VenihakiDepartment of Clinical Chemistry, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0002-3789-8032
Sotirios Tsiodras4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Dimitrios GeorgopoulosDepartment of Intensive Care Medicine, University Hospital of Heraklion and Medical School, University of Crete, 71110 Heraklion, Greece.
Marina MantzouraniFirst Department of Internal Medicine-Propaedeutic, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Serafeim NanasFirst Critical Care Department, Evangelismos University Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece.
Apostolos Armaganidis2nd Department of Critical Care, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
George L DaikosFirst Department of Internal Medicine-Propaedeutic, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Ioannis PapassotiriouDepartment of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.ORCID 0000-0002-2126-3251
George BriassoulisPediatric Intensive Care Unit, University Hospital of Heraklion and School of Medicine, University of Crete, 71110 Heraklion, Greece.
University of Crete · GRNational and Kapodistrian University of Athens · GRChildren's Hospital Agia Sophia · GR
Funding
Special Account for Research Funds of the University of 356 Crete KA 4975
Abstract
Oxidative stress is considered pivotal in the pathophysiology of sepsis. Oxidants modulate heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis. This multicenter prospective observational study was designed to ascertain whether an oxidant/antioxidant imbalance is an independent sepsis discriminator and mortality predictor in intensive care unit (ICU) patients with sepsis (
Indexed as
antioxidant statusapoptosisheat shock proteinsinnate immunityinterleukinsoxidative stressTACTOS
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.