Evidence map›Paper›PMID 35204093›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Nrf2 Is Required for Optimal Alveolar-Macrophage-Mediated Apoptotic Neutrophil Clearance after Oxidant Injury.

Narsa M Reddy, Chandra Mohan Tamatam, Ankireddy Aparna, Sekhar P Reddy

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects of neutrophil fate on inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Narsa M ReddyDepartment of Pediatrics, College of Medicine, The University of Illinois Chicago, Chicago, IL 60612, USA.
Chandra Mohan TamatamDepartment of Pediatrics, College of Medicine, The University of Illinois Chicago, Chicago, IL 60612, USA.
Ankireddy AparnaDepartment of Pediatrics, College of Medicine, The University of Illinois Chicago, Chicago, IL 60612, USA.
Sekhar P ReddyDepartment of Pediatrics, College of Medicine, The University of Illinois Chicago, Chicago, IL 60612, USA.
University of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

Human NRF2 Promoter Functional Polymorphisms and Acute Lung InjuryR01HL066109 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REDDY, SEKHAR P. · 2001 to 2012
$3.5M
Role of Nrf2 in Alveolar Epithelial Cell Regeneration During Lung RepairR01HL136946 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REDDY, SEKHAR P. · 2017 to 2020
$2.1M
Fra-1-A20 Signaling and Resolution of Pneumonia-Induced SepsisR01GM124235 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REDDY, SEKHAR P. · 2017 to 2020
$1.3M
American Heart Association RG-272303-NNational Institute of Health HL66109, HL136946, GM124235NHLBI NIH HHS R01 HL066109NHLBI NIH HHS R01 HL136946NIGMS NIH HHS R01 GM124235
6 · The paper itself

Abstract

Recognition and clearance of apoptotic cells by phagocytes (also known as efferocytosis), primarily mediated by macrophages, are essential to terminate lung inflammatory responses and promote tissue repair after injury. The Nrf2 transcription factor is crucial for cytoprotection and host defense. Previously, we showed sustained neutrophilic lung inflammation in Nrf2-deficient (

Indexed as

cell deathefferocytosisinflammation resolutionoxidant stressphosphatidylserine

Identifiers

PMID35204093
PMCPMC8868099
OpenAlexW4214551169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.