ArticleBrain sciences2022
Ethical Considerations in Clinical Trials for Disorders of Consciousness.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Common Consent Elements for Research Involving Persons with Disorders of Consciousness (CCE-DOC).Neurocritical care · 2026Article
- Article
- From fMRI to Family Meeting: Clinician and Family Perspectives on Neurotechnology-Informed Shared Decision-Making in Disorders of Consciousness.Neurocritical care · 2026Article
- Review
- Can digital brain twins dissolve the uncertainties surrounding unresponsive wakefulness?BMC medical ethics · 2026Article
- Therapeutic modulation of empathy: pharmacological, neurostimulation, and behavioral approaches.Frontiers in psychology · 2026Review
- Ethical Challenges in Research Involving Hospitalized Patients: A Phenomenological Study.Health care analysis : HCA : journal of health philosophy and policy · 2025Article
- Recruitment Challenges in Spinal Cord Stimulation Trial for Motor Recovery in Patients with Chronic Complete Spinal Cord Injury.Journal of clinical medicine · 2025Article
- Heart rate variability responses to personalized and non-personalized affective videos. A study on healthy subjects and patients with disorders of consciousness.Frontiers in psychology · 2025Article
- Equity in Clinical Care and Research Involving Persons with Disorders of Consciousness.Neurocritical care · 2024Review
- Disclosing Results of Tests for Covert Consciousness: A Framework for Ethical Translation.Neurocritical care · 2024Review
- Disorders of Consciousness Rehabilitation: Ethical Dimensions and Epistemic Dilemmas.Physical medicine and rehabilitation clinics of North America · 2024Review
- Deep Brain Stimulation for Consciousness Disorders; Technical and Ethical Considerations.Neuroethics · 2024Article
- Covert cortical processing: a diagnosis in search of a definition.Neuroscience of consciousness · 2024Article
- Covert consciousness.NeuroRehabilitation · 2024Article
- Ethics Along the Continuum of Research Involving Persons with Disorders of Consciousness.Neurocritical care · 2023Article
- Measuring Consciousness in the Intensive Care Unit.Neurocritical care · 2023Article
- The clinical and ethical challenges of treating comatose patients following severe brain injury.Acta neurochirurgica · 2023Article
- Repetitive transcranial magnetic stimulation over the posterior parietal cortex improves functional recovery in nonresponsive patients: A crossover, randomized, double-blind, sham-controlled study.Frontiers in neurology · 2023Article
- Neuroethics across the Disorders of Consciousness Care Continuum.Seminars in neurology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
As the clinical trial landscape for patients with disorders of consciousness (DoC) expands, consideration of associated ethical challenges and opportunities is of ever-increasing importance. Responsible conduct of research in the vulnerable population of persons with DoC, including those with coma, vegetative state/unresponsive wakefulness syndrome (VS/UWS), minimally conscious state (MCS), covert cortical processing (CCP), and cognitive motor dissociation (CMD), demands proactive deliberation of unique ethical issues that may arise and the adoption of robust protections to safeguard patients, surrogates, and other key stakeholders. Here we identify and critically evaluate four central categories of ethical considerations in clinical trials involving participants with DoC: (1) autonomy, respect for persons and informed consent of individuals with liminal consciousness; (2) balancing unknown benefits and risks, especially considering the epistemological gap between behavior and consciousness that complicates ordinary ascription of subjective states; (3) disclosure to surrogates and clinical teams of investigational results pertaining to consciousness; and (4) justice considerations, including equitable access to clinical trial enrollment across communities and geographies. We outline guiding principles and research opportunities for clinicians, neuroethicists, and researchers engaged in DoC clinical trials to advance ethical study design and deployment in this complex yet crucial area of investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.