ArticleBrain sciences2022
Concordance of Alzheimer's Disease Subtypes Produced from Different Representative Morphological Measures: A Comparative Study.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- A Convolutional Neural Network and Graph Convolutional Network Based Framework for AD Classification.Sensors (Basel, Switzerland) · 2023Article
- Diagnostic accuracy study of automated stratification of Alzheimer's disease and mild cognitive impairment via deep learning based on MRI.Annals of translational medicine · 2022Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundGray matter (GM) density and cortical thickness (CT) obtained from structural magnetic resonance imaging are representative GM morphological measures that have been commonly used in Alzheimer's disease (AD) subtype research. However, how the two measures affect the definition of AD subtypes remains unclear.
methodsA total of 180 AD patients from the ADNI database were used to identify AD subgroups. The subtypes were identified via a data-driven strategy based on the density features and CT features, respectively. Then, the similarity between the two features in AD subtype definition was analyzed.
resultsFour distinct subtypes were discovered by both density and CT features: diffuse atrophy AD, minimal atrophy AD (MAD), left temporal dominant atrophy AD (LTAD), and occipital sparing AD. The matched subtypes exhibited relatively high similarity in atrophy patterns and neuropsychological and neuropathological characteristics. They differed only in MAD and LTAD regarding the carrying of apolipoprotein E ε2.
conclusionsThe results verified that different representative morphological GM measurement methods could produce similar AD subtypes. Meanwhile, the influences of apolipoprotein E genotype, asymmetric disease progression, and their interactions should be considered and included in the AD subtype definition. This study provides a valuable reference for selecting features in future studies of AD subtypes.
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