Evidence map›Paper›PMID 35203879›Full record

ReviewAntibiotics (Basel, Switzerland)2022

The Role of Colistin in the Era of New β-Lactam/β-Lactamase Inhibitor Combinations.

Abdullah Tarık Aslan, Murat Akova

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06650384 (Evaluation of the Efficacy and Safety of N-Acetylcysteine Versus Alpha-Lipoic Acid on the Occurrence and Severity of Colistin-Induced Nephrotoxicity in Critically Ill Patients), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06650384 phase2 / phase3completednot on this mapstarted 2024, after this paper: background citation

Evaluation of the Efficacy and Safety of N-Acetylcysteine Versus Alpha-Lipoic Acid on the Occurrence and Severity of Colistin-Induced Nephrotoxicity in Critically Ill Patients

TypeinterventionalSponsorAin Shams UniversityRan2024 to 2026Enrolled180ConditionsNephrotoxicityArmsAddition of sachets of N-acetyl cysteine 1200 mg twice/day to the maintenance dose of colistin, Addition of Alpha-lipoic acid 600mg twice daily to the maintenance dose of colistin
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. High prevalence of colistin heteroresistance in Pseudomonas aeruginosa bloodstream isolates and associated clinical factors.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Antimicrobial Resistance Profiles ofPolish journal of microbiology · 2025
    Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Observational
  17. Observational
  18. Article
  19. Article
  20. Frontiers in medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Abdullah Tarık AslanDepartment of Internal Medicine, Gölhisar State Hospital, Gölhisar, Burdur 15100, Turkey.
Murat AkovaDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey.ORCID 0000-0002-6904-9473
Hacettepe University · TRSivas State Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the current crisis related to the emergence of carbapenem-resistant Gram-negative bacteria (CR-GNB), classical treatment approaches with so-called "old-fashion antibiotics" are generally unsatisfactory. Newly approved β-lactam/β-lactamase inhibitors (BLBLIs) should be considered as the first-line treatment options for carbapenem-resistant

Indexed as

carbapenem resistanceceftazidime-avibactamceftolozane-tazobactamcolistinimipenem-relebactammeropenem-vaborbactamβ-lactam/β-lactamase inhibitors

Identifiers

PMID35203879
PMCPMC8868358
OpenAlexW4213042513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.