ReviewAntibiotics (Basel, Switzerland)2022
Antibiotic Prophylaxis for Hepato-Biliopancreatic Surgery-A Systematic Review.
Review in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The E-AHPBA-ESSO-Innsbruck consensus recommendations on peri- and postoperative management following liver resection.The British journal of surgery · 2025Guideline
- FulminantAnnals of hepato-biliary-pancreatic surgery · 2026Article
- Development and Evaluation of Clinical Practice Guidelines for Patients Undergoing Hepatectomy.Healthcare (Basel, Switzerland) · 2026Article
- Should Preoperative Biliary Decontamination Be Considered to Minimize Morbidity and Mortality Following Pancreatoduodenectomy?Antibiotics (Basel, Switzerland) · 2026Article
- Extended antibiotic prophylaxis beyond 24 h after pancreatic surgery: prevalence and risk factors.Frontiers in public health · 2026Article
- A real-world pharmacovigilance study of FDA adverse event reporting system events for cefazolin.Medicine · 2025Observational
- Piperacillin reaches high concentrations in bile and target tissues of the biliary system: an experimental study in pigs.Antimicrobial agents and chemotherapy · 2025Article
- Antibiotic prophylaxis for the prevention of surgical site infections following colorectal surgery: protocol for network meta-analysis of randomized trials.Systematic reviews · 2024Article
- Relationship between Intraoperative Bile Culture Outcomes and Subsequent Postoperative Infectious Complications: A Retrospective Cohort Study.BioMed research international · 2024Article
- Antibiotic prophylaxis after 48 h postoperatively are not associated with decreased surgical site infections and other healthcare associated infections in pancreatic surgery patients: a retrospective cohort study.Antimicrobial resistance and infection control · 2023Article
- Detection of Salmonella Typhi in Bile by Quantitative Real-Time PCR.Microbiology spectrum · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical site infections (SSIs) are among the most important determinants of morbidity after HBP surgery. Their frequency after HPB surgery is variable, from 1-2% after elective cholecystectomy to 25% after PD.
methodsA systematic review was performed to assess the role of antimicrobial prophylaxis (AP) in HPB elective surgery. Articles published between 2015 and 2021 were obtained; those before 2015 were not included because they antedate the WHO guidelines on SSI prevention. We conducted three different research methods for liver resection, elective cholecystectomy and pancreatic and biliary surgery regarding patients requiring preoperative biliary drainage.
resultsHepatic surgery, improvement in surgical technique and perioperative management lead to a very low SSI. One preoperative 2 g cefazolin dose may be adequate for surgical prophylaxis. From preoperative biliary drainage, we can derive that patients' homeostasis rather than AP plays a paramount role in reducing postoperative morbidity. The time from biliary drainage could be an essential element in decision making for surgical prophylaxis. In the case of low-risk cholecystectomy, it is not easy to draw definitive conclusions about the effect of AP. Data from the literature are inconsistent, and some risk factors cannot be predicted before surgery.
conclusionin our opinion, a strict preoperative cefazolin dose strategy can be reasonable in HBP surgery until a large-scale, multicentric RCT brings definitive conclusions.
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