Evidence map›Paper›PMID 35203756›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Assessment of In-Vitro Synergy of Fosfomycin with Meropenem, Amikacin and Tigecycline in Whole Genome Sequenced Extended and Pan Drug Resistant

Manawr Al-Quraini, Meher Rizvi, Zaaima Al-Jabri, Hiba Sami, Muna Al-Muzahmi, Zakariya Al-Muharrmi, Neelam Taneja, Ibrahim Al-Busaidi, Rajeev Soman

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
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  5. Mapping Antimicrobial Resistance inDiagnostics (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. A panel of diverseMicrobial genomics · 2023
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Manawr Al-QurainiDepartment of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Meher RizviDepartment of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Zaaima Al-JabriDepartment of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Hiba SamiDepartment of Microbiology, Jawahar Lal Nehru Medical College, AMU, Aligarh 202002, India.ORCID 0000-0002-4594-852X
Muna Al-MuzahmiDepartment of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Zakariya Al-MuharrmiDepartment of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Neelam TanejaDepartment of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Ibrahim Al-BusaidiInfectious Diseases Unit, Sultan Qaboos University Hospital, Muscat 123, Oman.ORCID 0000-0001-5126-1276
Rajeev SomanJupiter Hospital Pune, Deenanath Mangeshkar Hospital Pune, Bharati University, Pune 411045, India.
Sultan Qaboos University · OMDeenanath Mangeshkar Hospital and Research Center · INJawaharlal Nehru Medical College Hospital · INPost Graduate Institute of Medical Education and Research · INSultan Qaboos University Hospital · OM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fosfomycin has emerged as a very useful antimicrobial in management of extremely drug resistant (XDR) and pan drug resistant (PDR)

methodNon-replicate fully characterised 18 clinical isolates of

resultsFOS-MEM and FOS-AK both demonstrated excellent synergy against all PDRs and all but one XDR. Synergy led to lowering of MICs to susceptible breakpoints. FOS-TGC demonstrated antagonism. MLST-231

conclusionFOS + MEM and FOS + AK are excellent colistin sparing combinations against ST 231, ST-395 and ST-147 XDR and PDR

Indexed as

checkerboard assayfosfomycinin-vitro synergyKlebsiella pneumoniaemeropenemtime kill assay

Identifiers

PMID35203756
PMCPMC8868363
OpenAlexW4210817069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.