Evidence map›Paper›PMID 35203729›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Molecular Determinants for OMF Selectivity in Tripartite RND Multidrug Efflux Systems.

Esther Boyer, Jean Dessolin, Margaux Lustig, Marion Decossas, Gilles Phan, Quentin Cece, Grégory Durand, Véronique Dubois, Joris Sansen, Jean-Christophe Taveau and 3 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Targeting Siderophore Biosynthesis to Thwart Microbial Growth.International journal of molecular sciences · 2025
    Review
  3. Metabolic Rewiring ofMetabolites · 2024
    Review
  4. Mutations inAntimicrobial agents and chemotherapy · 2022
    Article
  5. Article
  6. Article
  7. Unraveling the mechanisms of intrinsic drug resistance inFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Esther BoyerCBMN UMR 5248, Bordeaux INP, CNRS, Université de Bordeaux, 33600 Pessac, France.ORCID 0000-0001-9952-3415
Jean DessolinCBMN UMR 5248, Bordeaux INP, CNRS, Université de Bordeaux, 33600 Pessac, France.
Margaux LustigLaboratoire CiTCoM, CNRS, Université de Paris, 75006 Paris, France.
Marion DecossasCBMN UMR 5248, Bordeaux INP, CNRS, Université de Bordeaux, 33600 Pessac, France.ORCID 0000-0003-0810-4309
Gilles PhanLaboratoire CiTCoM, CNRS, Université de Paris, 75006 Paris, France.ORCID 0000-0001-9683-4453
Quentin CeceLaboratoire CiTCoM, CNRS, Université de Paris, 75006 Paris, France.
Grégory DurandUnité Propre de Recherche et d'Innovation, Université d'Avignon, Equipe S2CB, 84916 Avignon, France.ORCID 0000-0001-6680-2821
Véronique DuboisMFP, UMR 5234, CNRS, Univiversité de Bordeaux, 33000 Bordeaux, France.
Joris SansenCBMN UMR 5248, Bordeaux INP, CNRS, Université de Bordeaux, 33600 Pessac, France.ORCID 0000-0003-4678-8182
Jean-Christophe TaveauCBMN UMR 5248, Bordeaux INP, CNRS, Université de Bordeaux, 33600 Pessac, France.
Isabelle BroutinLaboratoire CiTCoM, CNRS, Université de Paris, 75006 Paris, France.ORCID 0000-0001-9862-1232
Laetitia DauryCBMN UMR 5248, Bordeaux INP, CNRS, Université de Bordeaux, 33600 Pessac, France.
Olivier LambertCBMN UMR 5248, Bordeaux INP, CNRS, Université de Bordeaux, 33600 Pessac, France.ORCID 0000-0002-5651-8082
Centre National de la Recherche Scientifique · FRUniversité d'Avignon et des Pays de Vaucluse · FR

Funding

Agence Nationale de la Recherche ANR-17CE11-0028Agence Nationale de la Recherche ANR-17-CE18-0022-03
6 · The paper itself

Abstract

Tripartite multidrug RND efflux systems made of an inner membrane transporter, an outer membrane factor (OMF) and a periplasmic adaptor protein (PAP) form a canal to expel drugs across Gram-negative cell wall. Structures of MexA-MexB-OprM and AcrA-AcrB-TolC, from

Indexed as

antibiotic resistanceefflux pumpRND

Identifiers

PMID35203729
PMCPMC8868134
OpenAlexW4205347612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.