Evidence map›Paper›PMID 35203710›Full record

ArticleBiomedicines2022

Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain.

Miguel A Tejada, Ana I Santos-Llamas, Lesley Escriva, Juan J Tarin, Antonio Cano, Maria J Fernández-Ramírez, Paulina Nunez-Badinez, Bianca De Leo, Philippa T K Saunders, Victor Vidal and 7 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 3 countries.

Miguel A TejadaResearch Unit on Women's Health-INCLIVA, Institute of Health Research, 46010 Valencia, Spain.ORCID 0000-0002-9323-7626
Ana I Santos-LlamasResearch Unit on Women's Health-INCLIVA, Institute of Health Research, 46010 Valencia, Spain.
Lesley EscrivaResearch Unit on Women's Health-INCLIVA, Institute of Health Research, 46010 Valencia, Spain.
Juan J TarinResearch Unit on Women's Health-INCLIVA, Institute of Health Research, 46010 Valencia, Spain.
Antonio CanoResearch Unit on Women's Health-INCLIVA, Institute of Health Research, 46010 Valencia, Spain.ORCID 0000-0001-8046-0303
Maria J Fernández-RamírezDepartment of Pediatrics and Obstetrics and Gynecology, University of Valencia, 46010 Valencia, Spain.
Paulina Nunez-BadinezBayer AG. Research & Early Development, Pharmaceuticals, Reproductive Health, Müllerstr. 178, 13342 Berlin, Germany.
Bianca De LeoBayer AG. Research & Early Development, Pharmaceuticals, Reproductive Health, Müllerstr. 178, 13342 Berlin, Germany.ORCID 0000-0003-0500-5751
Philippa T K SaundersCentre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.ORCID 0000-0001-9051-9380
Victor VidalFaculty of Science, International University of La Rioja, Avda de la paz 137, 26006 Logrono, Spain.
Florent BarthasGrünenthal GmbH, 52099 Aachen, Germany.
Katy VincentNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford OX1 2JD, UK.
Patrick J SweeneyActual Analytics, 99 Giles Street, Edinburgh EH6 6BZ, UK.
Rowland R SillitoActual Analytics, 99 Giles Street, Edinburgh EH6 6BZ, UK.
James Douglas ArmstrongActual Analytics, 99 Giles Street, Edinburgh EH6 6BZ, UK.
Jens NagelBayer AG. Research & Early Development, Pharmaceuticals, Exploratory Pathobiology, Aprather Weg 18a, 42096 Wuppertal, Germany.
Raúl GomezResearch Unit on Women's Health-INCLIVA, Institute of Health Research, 46010 Valencia, Spain.ORCID 0000-0002-3798-5961
Universitat de València · ESBayer (Germany) · DEINCLIVA Health Research Institute · ESGrünenthal Group (Germany) · DEQueen's Medical Centre · GBUniversidad de La Rioja · ESUniversity of Edinburgh · GBUniversity of Oxford · GB

Funding

Innovative Medicines Initiative 777500Instituto de Salud Carlos III FI18/00322Instituto de Salud Carlos III PI17/02329Instituto de Salud Carlos III PI20/01835National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C011201/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C012108/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C012201/1Spanish Ministry of Economy and Competitiveness through the Miguel Servet Program CPII18/00037
6 · The paper itself

Abstract

The aim of this study was to develop and refine a heterologous mouse model of endometriosis-associated pain in which non-evoked responses, more relevant to the patient experience, were evaluated. Immunodeficient female mice (N = 24) were each implanted with four endometriotic human lesions (N = 12) or control tissue fat (N = 12) on the abdominal wall using tissue glue. Evoked pain responses were measured biweekly using von Frey filaments. Non-evoked responses were recorded weekly for 8 weeks using a home cage analysis (

Indexed as

endometriosisevoked and non-evoked responseheterologous modelpain

Identifiers

PMID35203710
PMCPMC8962432
OpenAlexW4213015560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.