Evidence map›Paper›PMID 35203638›Full record

ReviewBiomedicines2022

The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer.

Assiya Kussainova, Olga Bulgakova, Akmaral Aripova, Zumama Khalid, Rakhmetkazhi Bersimbaev, Alberto Izzotti

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Observational
  6. MicroRNAs in metabolism for precision treatment of lung cancer.Cellular & molecular biology letters · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Assiya KussainovaDepartment of Health Sciences, University of Genova, Via Pastore 1, 16132 Genoa, Italy.ORCID 0000-0002-1313-9779
Olga BulgakovaDepartment of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Nur-Sultan, Akmola 010008, Kazakhstan.ORCID 0000-0003-3272-0638
Akmaral AripovaDepartment of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Nur-Sultan, Akmola 010008, Kazakhstan.ORCID 0000-0003-1657-3543
Zumama KhalidDepartment of Health Sciences, University of Genova, Via Pastore 1, 16132 Genoa, Italy.ORCID 0000-0002-9019-4771
Rakhmetkazhi BersimbaevDepartment of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Nur-Sultan, Akmola 010008, Kazakhstan.
Alberto IzzottiDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-8588-0347
L. N. Gumilyov Eurasian National University · KZOspedale Policlinico San Martino · ITUniversity of Genoa · IT

Funding

Ministry of Education and Science of the Republic of Kazakhstan АР08856116
6 · The paper itself

Abstract

MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria and are probably derived from mitochondrial DNA. These miRNAs are able to directly regulate mitochondrial genes and mitochondrial activity. Mitochondrial dysfunction is the cause of many diseases, including cancer. In this review, we consider the role of mitochondrial miRNAs in the pathogenesis of lung cancer with particular reference to radon exposure.

Indexed as

lung cancermicroRNAmitochondrial microRNAradon

Identifiers

PMID35203638
PMCPMC8962319
OpenAlexW4213228902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.