Evidence map›Paper›PMID 35203628›Full record

ArticleBiomedicines2022

Neuron-Microglia Contacts Govern the PGE

Hsing-Chun Kuo, Kam-Fai Lee, Shiou-Lan Chen, Shu-Chen Chiu, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chun-Hsien Chu

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Targeting the COX-2/PGECancer immunology, immunotherapy : CII · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. The Cerebral Protective Effect of Novel Erinacines fromAntioxidants (Basel, Switzerland) · 2024
    Article
  6. Neural Correlates and Molecular Mechanisms of Memory and Learning.International journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Hsing-Chun KuoDivision of Basic Medical Sciences, Department of Nursing, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan.ORCID 0000-0002-8993-1615
Kam-Fai LeeDepartment of Pathology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
Shiou-Lan ChenGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University (KMU), Kaohsiung 80708, Taiwan.ORCID 0000-0003-3995-0276
Shu-Chen ChiuNational Laboratory Animal Center (NLAC), NARLabs, Tainan 74147, Taiwan.
Li-Ya LeeGrape King Biotechnology Inc (Grape King Bio Ltd.), Zhong-Li, Taoyuan 32542, Taiwan.
Wan-Ping ChenGrape King Biotechnology Inc (Grape King Bio Ltd.), Zhong-Li, Taoyuan 32542, Taiwan.ORCID 0000-0001-9043-4096
Chin-Chu ChenGrape King Biotechnology Inc (Grape King Bio Ltd.), Zhong-Li, Taoyuan 32542, Taiwan.
Chun-Hsien ChuInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70456, Taiwan.ORCID 0000-0003-2934-2584
Grape King (Taiwan) · TWChang Gung University of Science and Technology · TWChiayi Chang Gung Memorial Hospital · TWKaohsiung Medical University · TWNational Cheng Kung University · TWNational Institutes of Applied Research · TW

Funding

Ministry of Science and Technology (Taiwan) MOST 107-2320-B-006-046-MY3
6 · The paper itself

Abstract

Cellular and molecular mechanisms of the peripheral immune system (e.g., macrophage and monocyte) in programming endotoxin tolerance (ET) have been well studied. However, regulatory mechanism in development of brain immune tolerance remains unclear. The inducible COX-2/PGE

Indexed as

brain immunitycell–cell contactsCOX-2de novo protein synthesisendotoxin toleranceinnate immune memoryLPS binding proteinmicrogliaPGE2TLR4

Identifiers

PMID35203628
PMCPMC8962342
OpenAlexW4211105074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.