ReviewBiomedicines2022
Misuse of Anticholinergic Medications: A Systematic Review.
Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Toxidromes.Nature reviews. Disease primers · 2026Review
- Adverse outcomes between VMAT2 and anticholinergics in tardive dyskinesia: A target trial emulation.Psychiatry and clinical neurosciences · 2026Article
- Long-Term Cardiovascular Risks of Anticholinergic Versus Non-Anticholinergic Antidepressants: A Target Trial Emulation With Negative Control Correction.Pharmacoepidemiology and drug safety · 2026Article
- Temporal assessment of behavior in Parkinson's visual hallucinations via a multidimensional analysis strategy.Signal transduction and targeted therapy · 2026Article
- Brugmansia suaveolens Abuse in a Patient With Multiple Substance Use Disorders: A Case Report.Cureus · 2026Article
- Anticholinergic Burden at Admission and Discharge Among Geriatric Inpatients: A Single-Center Retrospective Cohort Study.International journal of general medicine · 2026Article
- Beyond anticholinergic effects: A case of trihexyphenidyl-induced bradycardia.Journal of family medicine and primary care · 2025Article
- Efficacy of Hyoscine N-butyl Bromide on Cervical Dilatation Prior to Hysteroscopy Procedure: An Open-Label Randomized Controlled Trial.International journal of fertility & sterility · 2025Article
- Profiling and assessing the risks of image- and performance-enhancing drugs use during the COVID-19 lockdown.Frontiers in public health · 2024Observational
- Trihexyphenidyl Alters Its Host's Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop-The Modulating Role ofAntioxidants (Basel, Switzerland) · 2023Article
- The acute effects of psychoactive drugs on emotional episodic memory encoding, consolidation, and retrieval: A comprehensive review.Neuroscience and biobehavioral reviews · 2023Review
- Article
- The Medication Use Issues and Challenges of Mental Illness Exacerbation in Patients with Schizophrenia: A Qualitative Study in Thailand.Patient preference and adherence · 2023Article
- Aberrant salience in cannabis-induced psychosis: a comparative study.Frontiers in psychiatry · 2023Article
- Editorial: Prescribing psychotropics: Misuse, abuse, dependence, withdrawal and addiction, Volume II.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: Over the last decade, misuse and diversion of medications has appeared to be increasingly concerning phenomena, including a range of different molecules. As current knowledge on the abuse of centrally acting anticholinergics is limited, the aim of the present study is to review the relevant published data, focusing on the following molecules: benztropine, biperiden, scopolamine, orphenadrine, and benzhexol/trihexyphenidyl (THP). (2) Methods: A systematic literature review was carried out using Pubmed, Scopus, and Web of Science databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Research methods were registered on PROSPERO (CRD42021257293). (3) Results: A total of 48 articles, including case reports, surveys, and retrospective case series analyses, were included. Most articles focused on benzhexol/THP (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.