Evidence map›Paper›PMID 35203445›Full record

ReviewBiomedicines2022

Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response.

Mateusz Szczerba, Sambhavi Subramanian, Kelly Trainor, Megan McCaughan, Karen V Kibler, Bertram L Jacobs

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. The strategies and advances of mRNA translation booster.Asian journal of pharmaceutical sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Beyond survival to domination:Frontiers in microbiology · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Transcriptome and proteomic analysis of mpox virus F3L-expressing cells.Frontiers in cellular and infection microbiology · 2024
    Article
  16. Article
  17. Review
  18. Review
  19. ZBP1 and heatstroke.Frontiers in immunology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mateusz SzczerbaBiodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ 85281, USA.
Sambhavi SubramanianBiodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ 85281, USA.
Kelly TrainorBiodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ 85281, USA.
Megan McCaughanBiodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ 85281, USA.
Karen V KiblerBiodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ 85281, USA.
Bertram L JacobsBiodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ 85281, USA.
Arizona State University · USCommunity College of Philadelphia · US

Funding

Monkeypox virus, Interferon, and NecroptosisR01AI095394 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI JACOBS, BERTRAM L. · 2012 to 2024
$4.9M
Role of the E3L gene in poxvirus pathogenesisR01AI052347 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI JACOBS, BERTRAM L. · 2003 to 2007
$1.6M
Infectious Disease Society of America G09516-300NIAID NIH HHS R01 AI052347NIAID NIH HHS R01 AI095394NIH HHS R01AI095394
6 · The paper itself

Abstract

Poxviridae have developed a plethora of strategies to evade innate and adaptive immunity. In this review, we focused on the vaccinia virus E3 protein, encoded by the

Indexed as

host rangeinnate immunityinterferonnecroptosispathogenesisPKRvaccinia virusviral immune evasionZBP1Z-RNA

Identifiers

PMID35203445
PMCPMC8869630
OpenAlexW4214521417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.