Evidence map›Paper›PMID 35203438›Full record

ReviewBiomedicines2022

Novel Therapeutic Approaches to Psoriasis and Risk of Infectious Disease.

Alfonso Motolese, Manuela Ceccarelli, Laura Macca, Federica Li Pomi, Ylenia Ingrasciotta, Giuseppe Nunnari, Claudio Guarneri

Abstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  9. Secondary immunodeficiencies and infectious considerations of biologic immunomodulatory therapies.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Review
  10. Article
  11. Review
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alfonso MotoleseDepartment of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy C/O A.O.U.P. "Gaetano Martino", via Consolare Valeria, 1, 98125 Messina, Italy.
Manuela CeccarelliDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Catania, Catania, Italy C/O ARNAS "Garibaldi", "Nesima" Hospital, via Palermo 636, 95122 Catania, Italy.
Laura MaccaDepartment of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy C/O A.O.U.P. "Gaetano Martino", via Consolare Valeria, 1, 98125 Messina, Italy.ORCID 0000-0001-6470-8751
Federica Li PomiDepartment of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy C/O A.O.U.P. "Gaetano Martino", via Consolare Valeria, 1, 98125 Messina, Italy.ORCID 0000-0001-6760-9468
Ylenia IngrasciottaDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Pharmacology, University of Messina, Messina, Italy C/O A.O.U.P. "Gaetano Martino", via Consolare Valeria, 1, 98125 Messina, Italy.
Giuseppe NunnariDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Messina, Italy C/O A.O.U.P. "Gaetano Martino", via Consolare Valeria, 1, 98124 Messina, Italy.
Claudio GuarneriDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Dermatology, University of Messina, Messina, Italy C/O A.O.U.P. "Gaetano Martino", via Consolare Valeria, 1, 98125 Messina, Italy.ORCID 0000-0003-3918-8779

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a chronic immune-mediated skin and joint disease, with a plethora of comorbidities, characterized by a certain genetic predisposition, and a complex pathogenesis based on the IL-23/IL-17 pathway. There is no doubt that the patients affected by psoriasis are more susceptible to infections as well as that the risk of infection is higher in psoriatic subjects than in the general population. The advent of biotechnological agents on the therapeutic arsenal actually available for the treatment of moderate-to-severe patients, given the fact that the severity of the disease is a predictor of the level of infectious risk, has raised the question of whether these 'new' drugs could be considered a safer option and how they can be used in selected cases. Old and newer strategies in cases of chronic infectious conditions are reviewed under the light of clinical trials and other studies present in literature.

Indexed as

anti-IL12/23anti-IL-17antiIL-23anti-JAKanti-PDE4anti-TNF-αCOVID-19HBVHCVHIVinfectionspsoriasistuberculosis

Identifiers

PMID35203438
PMCPMC8869084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.