Evidence map›Paper›PMID 35203391›Full record

ArticleCells2022

Sustained Elevated Circulating Activin A Impairs Global Longitudinal Strain in Pregnant Rats: A Potential Mechanism for Preeclampsia-Related Cardiac Dysfunction.

Bhavisha A Bakrania, Ana C Palei, Umesh Bhattarai, Yingjie Chen, Joey P Granger, Sajid Shahul

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Bhavisha A BakraniaUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane 4029, Australia.ORCID 0000-0002-2534-004X
Ana C PaleiDepartment of Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0002-2669-5301
Umesh BhattaraiDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Yingjie ChenDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Joey P GrangerDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Sajid ShahulDepartment of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA.
Jackson Memorial Hospital · USThe University of Queensland · AUUniversity of Chicago · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HALL, JOHN E · 1993 to 2018
$39.4M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Guideline-directed management and therapy (GDMT) for the prevention of postpartum cardiac dysfunction in preeclamptic African American womenR01HL148191 · NHLBI · UNIVERSITY OF CHICAGO · PI SHAHUL, SAJID · 2021 to 2025
$3.8M
Mechanisms of Treg and IL-35 in Regulating LV Failure-induced Lung Remodeling and Right Heart HypertrophyR01HL139797 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, YINGJIE · 2018 to 2021
$2.2M
American Heart Association 18POST33990293NHLBI NIH HHS P01 HL051971NHLBI NIH HHS R01 HL139797NHLBI NIH HHS R01 HL148191NIGMS NIH HHS P20 GM104357NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Mediators of cardiac injury in preeclampsia are not well understood. Preeclamptic women have decreased cardiac global longitudinal strain (GLS), a sensitive measure of systolic function that indicates fibrosis and tissue injury. GLS is worse in preeclampsia compared to gestational hypertension, despite comparable blood pressure, suggesting that placental factors may be involved. We previously showed that Activin A, a pro-fibrotic factor produced in excess by the placenta in preeclampsia, predicts impaired GLS postpartum. Here, we hypothesized that chronic excess levels of Activin A during pregnancy induces cardiac dysfunction. Rats were assigned to sham or activin A infusion (1.25-6 µg/day) on a gestational day (GD) 14 (

Indexed as

ActivinsHeart DiseasesPre-EclampsiaAnimalsFemaleHumansPlacentaPregnancyRatsactivin AActivinsactivin Acardiac dysfunctionplacental factorspreeclampsia

Identifiers

PMID35203391
PMCPMC8870359
OpenAlexW4212842994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.