ArticleCells2022
L-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects.
Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- A pilot study on early microgliogenesis following unilateral vestibular neurectomy: A key player in vestibular compensation?PloS one · 2026Article
- Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation.Molecular neurobiology · 2024Review
- [Research advances in the mechanism of vestibular compensation and treatment].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Statistical Associations between Vestibular Pathologies and Hypothyroidism: A Retrospective Study.Journal of clinical medicine · 2024Article
- The Vestibular Nuclei: A Cerebral Reservoir of Stem Cells Involved in Balance Function in Normal and Pathological Conditions.International journal of molecular sciences · 2024Review
- Histaminergic System and Vestibular Function in Normal and Pathological Conditions.Current neuropharmacology · 2024Review
- Chronic Vestibular Hypofunction Is Associated with Impaired Sleep: Results from the DizzyReg Patient Registry.Journal of clinical medicine · 2023Article
- Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology.International journal of molecular sciences · 2023Review
- Differential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation.Biomedicines · 2023Article
- The Physiological Functions and Polymorphisms of Type II Deiodinase.Endocrinology and metabolism (Seoul, Korea) · 2023Review
- Vestibular Disorders and Hormonal Dysregulations: State of the Art and Clinical Perspectives.Cells · 2023Review
- Oxytocin Disturbs Vestibular Compensation and Modifies Behavioral Strategies in a Rodent Model of Acute Vestibulopathy.International journal of molecular sciences · 2022Article
- Vestibular Nuclei: A New Neural Stem Cell Niche?Cells · 2022Article
- Frontiers in Neurogenesis.Cells · 2022Article
- Article
- Characterization of Thyroid Hormones Antivertigo Effects in a Rat Model of Excitotoxically-Induced Vestibulopathy.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-term L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Thyroid hormone receptors (TRα and TRβ) and type II iodothyronine deiodinase (DIO2) were present in the vestibular nuclei (VN), supporting a local action of L-T4. We confirmed the T4-induced metabolic effects by demonstrating an increase in the number of cytochrome oxidase-labeled neurons in the VN three days after the lesion. L-T4 treatment modulated glial reaction by decreasing both microglia and oligodendrocytes in the deafferented VN three days after UVN and increased cell proliferation. Survival of newly generated cells in the deafferented vestibular nuclei was not affected, but microglial rather than neuronal differentiation was favored by L-T4 treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.