Evidence map›Paper›PMID 35203284›Full record

ArticleCells2022

Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System.

Benjamin P Lüscher, Christiane Albrecht, Bruno Stieger, Daniel V Surbek, Marc U Baumann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Benjamin P LüscherDepartment of Obstetrics and Gynecology, University Hospital of Bern, University of Bern, CH-3010 Bern, Switzerland.
Christiane AlbrechtInstitute of Biochemistry and Molecular Medicine, University of Bern, CH-3012 Bern, Switzerland.ORCID 0000-0002-7846-6930
Bruno StiegerSwiss National Center of Competence in Research, NCCR TransCure, University of Bern, CH-3012 Bern, Switzerland.
Daniel V SurbekDepartment of Obstetrics and Gynecology, University Hospital of Bern, University of Bern, CH-3010 Bern, Switzerland.
Marc U BaumannDepartment of Obstetrics and Gynecology, University Hospital of Bern, University of Bern, CH-3010 Bern, Switzerland.
University of Bern · CH

Funding

Swiss National Science Foundation 51NF40- 185544
6 · The paper itself

Abstract

backgroundHyperuricemia is a common laboratory finding in pregnant women compromised by preeclampsia. A growing body of evidence suggests that uric acid is involved in the pathogenesis of preeclampsia. Glucose transporter 9 (GLUT9) is a high-capacity uric acid transporter. The aim of this study was to investigate the placental uric acid transport system, and to identify the (sub-) cellular localization of GLUT9.

methodsSpecific antibodies against GLUT9a and GLUT9b isoforms were raised, and human villous (placental) tissue was immunohistochemically stained. A systemic GLUT9 knockout (G9KO) mouse model was used to assess the placental uric acid transport capacity by measurements of uric acid serum levels in the fetal and maternal circulation.

resultsGLUT9a and GLUT9b co-localized with the villous (apical) membrane, but not with the basal membrane, of the syncytiotrophoblast. Fetal and maternal uric acid serum levels were closely correlated. G9KO fetuses showed substantially higher uric acid serum concentrations than their mothers.

conclusionsThese findings demonstrate that the placenta efficiently maintains uric acid homeostasis, and that GLUT9 plays a key role in the placental uric acid transport system, at least in this murine model. Further studies investigating the role of the placental uric acid transport system in preeclampsia are eagerly needed.

Indexed as

Glucose Transport Proteins, FacilitativeHyperuricemiaPre-EclampsiaAnimalsFemaleHumansMiceMice, KnockoutPlacentaPregnancyUric AcidGlucose Transport Proteins, FacilitativeSLC2A9 protein, humanSlc2a9 protein, mouseUric Acidglucose transporter 9GLUT9preeclampsiauric acid

Identifiers

PMID35203284
PMCPMC8870656
OpenAlexW4213082229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.