Evidence map›Paper›PMID 35203267›Full record

ArticleCells2022

Synergistic Cytokine Production by ATP and PGE

Kosuke Obayashi, Kazuki Yoshida, Masa-Aki Ito, Tetsuya Mori, Kimiko Yamamoto, Toshiyashu Imai, Isao Matsuoka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kosuke ObayashiLaboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan.
Kazuki YoshidaLaboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan.ORCID 0000-0001-7785-5021
Masa-Aki ItoLaboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan.
Tetsuya MoriLaboratory of Allergy and Immunology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan.
Kimiko YamamotoDepartment of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Toshiyashu ImaiDiscovery Research Laboratories, Nippon Chemiphar Co., Ltd., Misato 341-0005, Saitama, Japan.
Isao MatsuokaLaboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan.ORCID 0000-0002-7170-3630
Takasaki University of Health and Welfare · JPNippon Chemiphar (Japan) · JPThe University of Tokyo · JP

Funding

Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research
6 · The paper itself

Abstract

ATP is an important intercellular messenger in the extracellular space. In mast cells (MCs), ATP stimulates the ionotropic P2X4 receptor (P2X4R), resulting in enhanced degranulation and exacerbation of acute allergic reactions. In this study, we investigate whether ATP regulates inflammatory cytokine production in MCs. Gene expression was analyzed by quantitative RT-PCR, and cytokine production was measured using ELISA. The stimulation of mouse bone-marrow-derived MCs (BMMCs) with ATP alone had little effect on cytokine secretion. However, the co-stimulation with prostaglandin (PG) E

Indexed as

Cell DegranulationCytokinesMast CellsReceptors, Prostaglandin E, EP3 SubtypeReceptors, Purinergic P2X4Adenosine TriphosphateAnimalsBone MarrowDinoprostoneGene ExpressionInterleukin-6MiceRNA, MessengerAdenosine TriphosphateCytokinesDinoprostoneInterleukin-6Ptger3 protein, mouseReceptors, Prostaglandin E, EP3 SubtypeReceptors, Purinergic P2X4RNA, MessengerATPbone-marrow-derived mast cellsEP3 receptorP2X4 receptorprostaglandin E2

Identifiers

PMID35203267
PMCPMC8870111
OpenAlexW4211220420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.